Cargando…

SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: a new route of epigenomic regulation

The serum- and glucocorticoid-regulated kinase (SGK1) controls cell transformation and tumor progression. SGK1 affects mitotic stability by regulating the expression of RANBP1/RAN. Here, we demonstrate that SGK1 fluctuations indirectly modify the maturation of pre-miRNAs, by modulating the equilibri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dattilo, Vincenzo, D’Antona, Lucia, Talarico, Cristina, Capula, Mjriam, Catalogna, Giada, Iuliano, Rodolfo, Schenone, Silvia, Roperto, Sante, Bianco, Cataldo, Perrotti, Nicola, Amato, Rosario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371792/ https://www.ncbi.nlm.nih.gov/pubmed/28358001 http://dx.doi.org/10.1038/srep45361

Ejemplares similares

RANBP1 (RAN Binding Protein 1): The Missing Genetic Piece in Cancer Pathophysiology and Other Complex Diseases
por: Audia, Salvatore, et al.
Publicado: (2023)

RANBP1, a member of the nuclear-cytoplasmic trafficking-regulator complex, is the terminal-striking point of the SGK1-dependent Th17(+) pathological differentiation
por: Brescia, Carolina, et al.
Publicado: (2023)

RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly
por: Swaminathan, Sowmya, et al.
Publicado: (2004)

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes
por: Ritterhoff, Tobias, et al.
Publicado: (2016)

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1
por: He, Yujiao, et al.
Publicado: (2021)

In Preclinical Model of Ovarian Cancer, the SGK1 Inhibitor SI113 Counteracts the Development of Paclitaxel Resistance and Restores Drug Sensitivity
por: D'Antona, Lucia, et al.
Publicado: (2019)

The Cellular Distribution of RanGAP1 Is Regulated by CRM1-Mediated Nuclear Export in Mammalian Cells
por: Cha, Keith, et al.
Publicado: (2015)

Determinants of Small Ubiquitin-like Modifier 1 (SUMO1) Protein Specificity, E3 Ligase, and SUMO-RanGAP1 Binding Activities of Nucleoporin RanBP2
por: Gareau, Jaclyn R., et al.
Publicado: (2012)

A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1
Publicado: (1996)

SUMOylation mediates the disassembly of the Smad4 nuclear export complex via RanGAP1 in KELOIDS
por: Lin, Xiaohu, et al.
Publicado: (2023)

SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles
por: Joseph, Jomon, et al.
Publicado: (2002)

SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells
por: Talarico, Cristina, et al.
Publicado: (2016)

Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy
por: Talarico, Cristina, et al.
Publicado: (2015)

RanBP3 enhances nuclear export of active β-catenin independently of CRM1
por: Hendriksen, Jolita, et al.
Publicado: (2005)

Distinct RanBP1 nuclear export and cargo dissociation mechanisms between fungi and animals
por: Li, Yuling, et al.
Publicado: (2019)

RanBP1 Couples Nuclear Export and Golgi Regulation through LKB1 to Promote Cortical Neuron Polarity
por: Mencarelli, Chiara, et al.
Publicado: (2018)

SUMO-1 Modification and Its Role in Targeting the Ran GTPase-activating Protein, RanGAP1, to the Nuclear Pore Complex
por: Matunis, Michael J., et al.
Publicado: (1998)

RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import
Publicado: (1996)

Molecular Characterization of the SUMO-1 Modification of RanGAP1 and Its Role in Nuclear Envelope Association
por: Mahajan, Rohit, et al.
Publicado: (1998)

RanBP1 controls the Ran pathway in mammalian cells through regulation of mitotic RCC1 dynamics
por: Yau, Ka Chun, et al.
Publicado: (2020)

A Role for RanBP1 in the Release of CRM1 from the Nuclear Pore Complex in a Terminal Step of Nuclear Export
por: Kehlenbach, Ralph H., et al.
Publicado: (1999)

The Emerging Role of SGK1 (Serum- and Glucocorticoid-Regulated Kinase 1) in Major Depressive Disorder: Hypothesis and Mechanisms
por: Dattilo, Vincenzo, et al.
Publicado: (2020)

CD147 supports paclitaxel resistance via interacting with RanBP1
por: Nan, Gang, et al.
Publicado: (2022)

The GTPase Activating Rap/RanGAP Domain-Like 1 Gene Is Associated with Chicken Reproductive Traits
por: Shen, Xu, et al.
Publicado: (2012)

Insights into the Function of the CRM1 Cofactor RanBP3 from the Structure of Its Ran-Binding Domain
por: Langer, Karla, et al.
Publicado: (2011)

RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction
por: Woo, J A, et al.
Publicado: (2015)

A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex
Publicado: (1996)

RanBP2 Modulates Cox11 and Hexokinase I Activities and Haploinsufficiency of RanBP2 Causes Deficits in Glucose Metabolism
por: Aslanukov, Azamat, et al.
Publicado: (2006)

Nicotiana benthamiana RanBP1-1 Is Involved in the Induction of Disease Resistance via Regulation of Nuclear-Cytoplasmic Transport of Small GTPase Ran
por: Mizuno, Yuri, et al.
Publicado: (2019)

The Cyst Nematode SPRYSEC Protein RBP-1 Elicits Gpa2- and RanGAP2-Dependent Plant Cell Death
por: Sacco, Melanie Ann, et al.
Publicado: (2009)

RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma
por: Kahm, Yeon-Jee, et al.
Publicado: (2023)

The Ran GTPase-Activating Protein (RanGAP1) Is Critically Involved in Smooth Muscle Cell Differentiation, Proliferation and Migration following Vascular Injury: Implications for Neointima Formation and Restenosis
por: Vorpahl, Marc, et al.
Publicado: (2014)

Novel plant SUN–KASH bridges are involved in RanGAP anchoring and nuclear shape determination
por: Zhou, Xiao, et al.
Publicado: (2012)

Roles of Nucleoporin RanBP2/Nup358 in Acute Necrotizing Encephalopathy Type 1 (ANE1) and Viral Infection
por: Jiang, Jing, et al.
Publicado: (2022)

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity
por: Gloerich, Martijn, et al.
Publicado: (2011)

RanBP2 stops importin-β from running away
por: Leslie, Mitch
Publicado: (2011)

Workshop on RanBP2/Nup358 and acute necrotizing encephalopathy
por: Palazzo, Alexander F., et al.
Publicado: (2022)

RanBP9 controls the oligomeric state of CTLH complex assemblies
por: van gen Hassend, Pia Maria, et al.
Publicado: (2023)

Determination of SGK1 mRNA in non-small cell lung cancer samples underlines high expression in squamous cell carcinomas
por: Abbruzzese, Claudia, et al.
Publicado: (2012)

Arabidopsis RanBP2-Type Zinc Finger Proteins Related to Chloroplast RNA Editing Factor OZ1
por: Gipson, Andrew B., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_059osr63t93lnnuooresv4s321