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Non-Canonical Roles of Dengue Virus Non-Structural Proteins
The Flaviviridae family comprises a number of human pathogens, which, although sharing structural and functional features, cause diseases with very different outcomes. This can be explained by the plurality of functions exerted by the few proteins coded by viral genomes, with some of these functions...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371797/ https://www.ncbi.nlm.nih.gov/pubmed/28335410 http://dx.doi.org/10.3390/v9030042 |
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author | Zeidler, Julianna D. Fernandes-Siqueira, Lorena O. Barbosa, Glauce M. Da Poian, Andrea T. |
author_facet | Zeidler, Julianna D. Fernandes-Siqueira, Lorena O. Barbosa, Glauce M. Da Poian, Andrea T. |
author_sort | Zeidler, Julianna D. |
collection | PubMed |
description | The Flaviviridae family comprises a number of human pathogens, which, although sharing structural and functional features, cause diseases with very different outcomes. This can be explained by the plurality of functions exerted by the few proteins coded by viral genomes, with some of these functions shared among members of a same family, but others being unique for each virus species. These non-canonical functions probably have evolved independently and may serve as the base to the development of specific therapies for each of those diseases. Here it is discussed what is currently known about the non-canonical roles of dengue virus (DENV) non-structural proteins (NSPs), which may account for some of the effects specifically observed in DENV infection, but not in other members of the Flaviviridae family. This review explores how DENV NSPs contributes to the physiopathology of dengue, evasion from host immunity, metabolic changes, and redistribution of cellular components during infection. |
format | Online Article Text |
id | pubmed-5371797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53717972017-04-10 Non-Canonical Roles of Dengue Virus Non-Structural Proteins Zeidler, Julianna D. Fernandes-Siqueira, Lorena O. Barbosa, Glauce M. Da Poian, Andrea T. Viruses Review The Flaviviridae family comprises a number of human pathogens, which, although sharing structural and functional features, cause diseases with very different outcomes. This can be explained by the plurality of functions exerted by the few proteins coded by viral genomes, with some of these functions shared among members of a same family, but others being unique for each virus species. These non-canonical functions probably have evolved independently and may serve as the base to the development of specific therapies for each of those diseases. Here it is discussed what is currently known about the non-canonical roles of dengue virus (DENV) non-structural proteins (NSPs), which may account for some of the effects specifically observed in DENV infection, but not in other members of the Flaviviridae family. This review explores how DENV NSPs contributes to the physiopathology of dengue, evasion from host immunity, metabolic changes, and redistribution of cellular components during infection. MDPI 2017-03-13 /pmc/articles/PMC5371797/ /pubmed/28335410 http://dx.doi.org/10.3390/v9030042 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zeidler, Julianna D. Fernandes-Siqueira, Lorena O. Barbosa, Glauce M. Da Poian, Andrea T. Non-Canonical Roles of Dengue Virus Non-Structural Proteins |
title | Non-Canonical Roles of Dengue Virus Non-Structural Proteins |
title_full | Non-Canonical Roles of Dengue Virus Non-Structural Proteins |
title_fullStr | Non-Canonical Roles of Dengue Virus Non-Structural Proteins |
title_full_unstemmed | Non-Canonical Roles of Dengue Virus Non-Structural Proteins |
title_short | Non-Canonical Roles of Dengue Virus Non-Structural Proteins |
title_sort | non-canonical roles of dengue virus non-structural proteins |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371797/ https://www.ncbi.nlm.nih.gov/pubmed/28335410 http://dx.doi.org/10.3390/v9030042 |
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