Influence of DPH1 and DPH5 Protein Variants on the Synthesis of Diphthamide, the Target of ADP-Ribosylating Toxins

The diphthamide on eukaryotic translation elongation factor 2 (eEF2) is the target of ADP-ribosylating toxins and -derivatives that serve as payloads in targeted tumor therapy. Diphthamide is generated by seven DPH proteins; cells deficient in these (DPHko) lack diphthamide and are toxin-resistant....

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Detalles Bibliográficos
Autores principales: Mayer, Klaus, Schröder, Anna, Schnitger, Jerome, Stahl, Sebastian, Brinkmann, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371833/
https://www.ncbi.nlm.nih.gov/pubmed/28245596
http://dx.doi.org/10.3390/toxins9030078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371833/
https://www.ncbi.nlm.nih.gov/pubmed/28245596
http://dx.doi.org/10.3390/toxins9030078

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