Haemophagocytic lymphohistiocytosis associated with fulminant hepatitis and multiorgan failure following primary Epstein–Barr virus and herpes simplex virus type 1 infection

We present a case of severe fatal hepatitis in a young patient presumably triggered by two ubiquitous viral diseases which occurred in close succession. This case is unusual because of the exceptional chronological sequence of primary Epstein–Barr virus and herpes simplex virus type 1 infection caus...

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Autores principales: Honsig, Claudia, Beinhardt, Sandra, Tomasits, Josef, Dienes, Hans Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372189/
https://www.ncbi.nlm.nih.gov/pubmed/28356254
http://dx.doi.org/10.1136/bcr-2016-218310
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author Honsig, Claudia
Beinhardt, Sandra
Tomasits, Josef
Dienes, Hans Peter
author_facet Honsig, Claudia
Beinhardt, Sandra
Tomasits, Josef
Dienes, Hans Peter
author_sort Honsig, Claudia
collection PubMed
description We present a case of severe fatal hepatitis in a young patient presumably triggered by two ubiquitous viral diseases which occurred in close succession. This case is unusual because of the exceptional chronological sequence of primary Epstein–Barr virus and herpes simplex virus type 1 infection causing systemic immune dysregulation associated with rapidly developing liver failure and consecutive multiorgan failure. Clinical, laboratory and histopathological findings indicated the development of secondary haemophagocytic lymphohistiocytosis triggered by these closely succeeding viral primary infections.
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spelling pubmed-53721892017-04-12 Haemophagocytic lymphohistiocytosis associated with fulminant hepatitis and multiorgan failure following primary Epstein–Barr virus and herpes simplex virus type 1 infection Honsig, Claudia Beinhardt, Sandra Tomasits, Josef Dienes, Hans Peter BMJ Case Rep Article We present a case of severe fatal hepatitis in a young patient presumably triggered by two ubiquitous viral diseases which occurred in close succession. This case is unusual because of the exceptional chronological sequence of primary Epstein–Barr virus and herpes simplex virus type 1 infection causing systemic immune dysregulation associated with rapidly developing liver failure and consecutive multiorgan failure. Clinical, laboratory and histopathological findings indicated the development of secondary haemophagocytic lymphohistiocytosis triggered by these closely succeeding viral primary infections. BMJ Publishing Group 2017-03-29 /pmc/articles/PMC5372189/ /pubmed/28356254 http://dx.doi.org/10.1136/bcr-2016-218310 Text en 2017 BMJ Publishing Group Ltd This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Article
Honsig, Claudia
Beinhardt, Sandra
Tomasits, Josef
Dienes, Hans Peter
Haemophagocytic lymphohistiocytosis associated with fulminant hepatitis and multiorgan failure following primary Epstein–Barr virus and herpes simplex virus type 1 infection
title Haemophagocytic lymphohistiocytosis associated with fulminant hepatitis and multiorgan failure following primary Epstein–Barr virus and herpes simplex virus type 1 infection
title_full Haemophagocytic lymphohistiocytosis associated with fulminant hepatitis and multiorgan failure following primary Epstein–Barr virus and herpes simplex virus type 1 infection
title_fullStr Haemophagocytic lymphohistiocytosis associated with fulminant hepatitis and multiorgan failure following primary Epstein–Barr virus and herpes simplex virus type 1 infection
title_full_unstemmed Haemophagocytic lymphohistiocytosis associated with fulminant hepatitis and multiorgan failure following primary Epstein–Barr virus and herpes simplex virus type 1 infection
title_short Haemophagocytic lymphohistiocytosis associated with fulminant hepatitis and multiorgan failure following primary Epstein–Barr virus and herpes simplex virus type 1 infection
title_sort haemophagocytic lymphohistiocytosis associated with fulminant hepatitis and multiorgan failure following primary epstein–barr virus and herpes simplex virus type 1 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372189/
https://www.ncbi.nlm.nih.gov/pubmed/28356254
http://dx.doi.org/10.1136/bcr-2016-218310
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