DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis

BACKGROUND: Multiple factors, including interactions between genetic and environmental risks, are important in susceptibility to rheumatoid arthritis (RA). However, the underlying mechanism is not fully understood. This study was undertaken to evaluate whether DNA methylation can mediate the interac...

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Detalles Bibliográficos
Autores principales: Meng, Weida, Zhu, Zaihua, Jiang, Xia, Too, Chun Lai, Uebe, Steffen, Jagodic, Maja, Kockum, Ingrid, Murad, Shahnaz, Ferrucci, Luigi, Alfredsson, Lars, Zou, Hejian, Klareskog, Lars, Feinberg, Andrew P., Ekström, Tomas J., Padyukov, Leonid, Liu, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372280/
https://www.ncbi.nlm.nih.gov/pubmed/28356135
http://dx.doi.org/10.1186/s13075-017-1276-2

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