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Bitterness and antibacterial activities of constituents from Evodia rutaecarpa

BACKGROUND: Bitter herbs are important in Traditional Chinese Medicine and the Electronic Tongue (e-Tongue) is an instrument that can be trained to evaluate bitterness of bitter herbs and their constituents. The aim of this research was to evaluate bitterness of limonoids and alkaloids from Evodia r...

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Autores principales: Liang, Xiaoguang, Li, Bo, Wu, Fei, Li, Tingzhao, Wang, Youjie, Ma, Qiang, Liang, Shuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372309/
https://www.ncbi.nlm.nih.gov/pubmed/28356098
http://dx.doi.org/10.1186/s12906-017-1701-8
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author Liang, Xiaoguang
Li, Bo
Wu, Fei
Li, Tingzhao
Wang, Youjie
Ma, Qiang
Liang, Shuang
author_facet Liang, Xiaoguang
Li, Bo
Wu, Fei
Li, Tingzhao
Wang, Youjie
Ma, Qiang
Liang, Shuang
author_sort Liang, Xiaoguang
collection PubMed
description BACKGROUND: Bitter herbs are important in Traditional Chinese Medicine and the Electronic Tongue (e-Tongue) is an instrument that can be trained to evaluate bitterness of bitter herbs and their constituents. The aim of this research was to evaluate bitterness of limonoids and alkaloids from Evodia rutaecarpa to demonstrate that they are main bitter material basic of E. rutaecarpa. METHODS: Nine compounds, including limonoids, indoloquinazoline alkaloids and quinolone alkaloids, were isolated, identified and analyzed by the e-Tongue. Additionally, the antibacterial activities of the nine compounds were evaluated against E. coli and S. aureus. RESULTS: All the nine compounds had bitter taste and antibacterial activities to some extent. Among them, limonoids, which were the bitterest compounds, had greater antibacterial activities than alkaloids. And there is a positive correlation between bitter taste and antibacterial activities. CONCLUSIONS: It was confirmed in our study that limonoids, indoloquinazoline alkaloids and quinolone alkaloids are main bitter material basic of E. rutaecarpa based on two evaluation methods of e-Tongue and antibacterial experiment. In addition, the e-Tongue technique is a suitable new method to measure bitter degree in herbs. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12906-017-1701-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-53723092017-03-31 Bitterness and antibacterial activities of constituents from Evodia rutaecarpa Liang, Xiaoguang Li, Bo Wu, Fei Li, Tingzhao Wang, Youjie Ma, Qiang Liang, Shuang BMC Complement Altern Med Research Article BACKGROUND: Bitter herbs are important in Traditional Chinese Medicine and the Electronic Tongue (e-Tongue) is an instrument that can be trained to evaluate bitterness of bitter herbs and their constituents. The aim of this research was to evaluate bitterness of limonoids and alkaloids from Evodia rutaecarpa to demonstrate that they are main bitter material basic of E. rutaecarpa. METHODS: Nine compounds, including limonoids, indoloquinazoline alkaloids and quinolone alkaloids, were isolated, identified and analyzed by the e-Tongue. Additionally, the antibacterial activities of the nine compounds were evaluated against E. coli and S. aureus. RESULTS: All the nine compounds had bitter taste and antibacterial activities to some extent. Among them, limonoids, which were the bitterest compounds, had greater antibacterial activities than alkaloids. And there is a positive correlation between bitter taste and antibacterial activities. CONCLUSIONS: It was confirmed in our study that limonoids, indoloquinazoline alkaloids and quinolone alkaloids are main bitter material basic of E. rutaecarpa based on two evaluation methods of e-Tongue and antibacterial experiment. In addition, the e-Tongue technique is a suitable new method to measure bitter degree in herbs. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12906-017-1701-8) contains supplementary material, which is available to authorized users. BioMed Central 2017-03-29 /pmc/articles/PMC5372309/ /pubmed/28356098 http://dx.doi.org/10.1186/s12906-017-1701-8 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Liang, Xiaoguang
Li, Bo
Wu, Fei
Li, Tingzhao
Wang, Youjie
Ma, Qiang
Liang, Shuang
Bitterness and antibacterial activities of constituents from Evodia rutaecarpa
title Bitterness and antibacterial activities of constituents from Evodia rutaecarpa
title_full Bitterness and antibacterial activities of constituents from Evodia rutaecarpa
title_fullStr Bitterness and antibacterial activities of constituents from Evodia rutaecarpa
title_full_unstemmed Bitterness and antibacterial activities of constituents from Evodia rutaecarpa
title_short Bitterness and antibacterial activities of constituents from Evodia rutaecarpa
title_sort bitterness and antibacterial activities of constituents from evodia rutaecarpa
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372309/
https://www.ncbi.nlm.nih.gov/pubmed/28356098
http://dx.doi.org/10.1186/s12906-017-1701-8
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