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Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer

BACKGROUND: Although chemotherapy represents a predominant anti-cancer therapeutic modality, drug treatment efficacy is often limited due to the development of resistant tumor cells. The pregnane X receptor (PXR) affects chemotherapeutic effects by regulating targets involved in drug metabolism and...

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Detalles Bibliográficos
Autores principales:	Dong, Yan, Wang, Zhe, Xie, Gan-feng, Li, Chong, Zuo, Wen-wei, Meng, Gang, Xu, Cheng-ping, Li, Jian-jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372326/ https://www.ncbi.nlm.nih.gov/pubmed/28356150 http://dx.doi.org/10.1186/s12943-017-0641-8

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