Analysis on regulatory network linked to Hpa gene in invasion and metastasis of colon cancer

Our purpose was to discuss the biological function of Hpa gene and its regulatory network in invasion and metastasis of colon cancer. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes database were used to perform functional annotation and pathway analysis on Hpa gene. Gene Ontology analysis...

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Detalles Bibliográficos
Autores principales: Zhang, Lei, Wu, Huili, Xiao, Xingguo, Li, Kunkun, Zhang, Yang, Zhang, Li, Wen, Tingyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372369/
https://www.ncbi.nlm.nih.gov/pubmed/28386173
http://dx.doi.org/10.1016/j.sjbs.2017.01.019
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author Zhang, Lei
Wu, Huili
Xiao, Xingguo
Li, Kunkun
Zhang, Yang
Zhang, Li
Wen, Tingyu
author_facet Zhang, Lei
Wu, Huili
Xiao, Xingguo
Li, Kunkun
Zhang, Yang
Zhang, Li
Wen, Tingyu
author_sort Zhang, Lei
collection PubMed
description Our purpose was to discuss the biological function of Hpa gene and its regulatory network in invasion and metastasis of colon cancer. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes database were used to perform functional annotation and pathway analysis on Hpa gene. Gene Ontology analysis results showed that Hpa plays a significant role in cellular component, molecular function and biological process; and combined with Kyoto Encyclopedia of Genes and Genomes database, regulatory network of angiogenesis of colon cancer was drawn out. Through analysis of regulatory network linked to angiogenesis in invasion and metastasis of colon cancer, the study lays foundation for further prevention, diagnosis and treatment of colon cancer.
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spelling pubmed-53723692017-04-06 Analysis on regulatory network linked to Hpa gene in invasion and metastasis of colon cancer Zhang, Lei Wu, Huili Xiao, Xingguo Li, Kunkun Zhang, Yang Zhang, Li Wen, Tingyu Saudi J Biol Sci Original Article Our purpose was to discuss the biological function of Hpa gene and its regulatory network in invasion and metastasis of colon cancer. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes database were used to perform functional annotation and pathway analysis on Hpa gene. Gene Ontology analysis results showed that Hpa plays a significant role in cellular component, molecular function and biological process; and combined with Kyoto Encyclopedia of Genes and Genomes database, regulatory network of angiogenesis of colon cancer was drawn out. Through analysis of regulatory network linked to angiogenesis in invasion and metastasis of colon cancer, the study lays foundation for further prevention, diagnosis and treatment of colon cancer. Elsevier 2017-03 2017-01-22 /pmc/articles/PMC5372369/ /pubmed/28386173 http://dx.doi.org/10.1016/j.sjbs.2017.01.019 Text en © 2017 King Saud University http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Zhang, Lei
Wu, Huili
Xiao, Xingguo
Li, Kunkun
Zhang, Yang
Zhang, Li
Wen, Tingyu
Analysis on regulatory network linked to Hpa gene in invasion and metastasis of colon cancer
title Analysis on regulatory network linked to Hpa gene in invasion and metastasis of colon cancer
title_full Analysis on regulatory network linked to Hpa gene in invasion and metastasis of colon cancer
title_fullStr Analysis on regulatory network linked to Hpa gene in invasion and metastasis of colon cancer
title_full_unstemmed Analysis on regulatory network linked to Hpa gene in invasion and metastasis of colon cancer
title_short Analysis on regulatory network linked to Hpa gene in invasion and metastasis of colon cancer
title_sort analysis on regulatory network linked to hpa gene in invasion and metastasis of colon cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372369/
https://www.ncbi.nlm.nih.gov/pubmed/28386173
http://dx.doi.org/10.1016/j.sjbs.2017.01.019
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