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NANOG Expression as a Responsive Biomarker during Treatment with Hedgehog Signal Inhibitor in Acute Myeloid Leukemia

Aberrant activation of the Hedgehog (Hh) signaling pathway is involved in the maintenance of leukemic stem cell (LSCs) populations. PF-0444913 (PF-913) is a novel inhibitor that selectively targets Smoothened (SMO), which regulates the Hh pathway. Treatment with PF-913 has shown promising results in...

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Detalles Bibliográficos
Autores principales:	Kakiuchi, Seiji, Minami, Yosuke, Miyata, Yoshiharu, Mizutani, Yu, Goto, Hideaki, Kawamoto, Shinichiro, Yakushijin, Kimikazu, Kurata, Keiji, Matsuoka, Hiroshi, Minami, Hironobu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372502/ https://www.ncbi.nlm.nih.gov/pubmed/28245563 http://dx.doi.org/10.3390/ijms18030486

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