Cargando…

Protective Effects of Ferulic Acid against Chronic Cerebral Hypoperfusion-Induced Swallowing Dysfunction in Rats

Ferulic acid (FA), a phenolic phytochemical, has been reported to exert antioxidative and neuroprotective effects. In this study, we investigated the protective effects of FA against the dysfunction of the swallowing reflex induced by ligation of bilateral common carotid arteries (2VO) in rats. In 2...

Descripción completa

Detalles Bibliográficos
Autores principales: Asano, Takashi, Matsuzaki, Hirokazu, Iwata, Naohiro, Xuan, Meiyan, Kamiuchi, Shinya, Hibino, Yasuhide, Sakamoto, Takeshi, Okazaki, Mari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372566/
https://www.ncbi.nlm.nih.gov/pubmed/28273833
http://dx.doi.org/10.3390/ijms18030550
_version_ 1782518644945715200
author Asano, Takashi
Matsuzaki, Hirokazu
Iwata, Naohiro
Xuan, Meiyan
Kamiuchi, Shinya
Hibino, Yasuhide
Sakamoto, Takeshi
Okazaki, Mari
author_facet Asano, Takashi
Matsuzaki, Hirokazu
Iwata, Naohiro
Xuan, Meiyan
Kamiuchi, Shinya
Hibino, Yasuhide
Sakamoto, Takeshi
Okazaki, Mari
author_sort Asano, Takashi
collection PubMed
description Ferulic acid (FA), a phenolic phytochemical, has been reported to exert antioxidative and neuroprotective effects. In this study, we investigated the protective effects of FA against the dysfunction of the swallowing reflex induced by ligation of bilateral common carotid arteries (2VO) in rats. In 2VO rats, topical administration of water or citric acid to the pharyngolaryngeal region evoked a diminished number of swallowing events with prolonged latency compared to sham-operated control rats. 2VO rats had an increased level of superoxide anion radical, and decreased dopamine and tyrosine hydroxylase enzyme levels in the striatum, suggesting that 2VO augmented cerebral oxidative stress and impaired the striatal dopaminergic system. Furthermore, substance P (SP) expression in the laryngopharyngeal mucosa, which is believed to be positively regulated by dopaminergic signaling in the basal ganglia, was decreased in 2VO rats. Oral treatment with FA (30 mg/kg) for 3 weeks (from one week before 2VO to two weeks after) improved the swallowing reflex and maintained levels of striatal dopamine and laryngopharyngeal SP expression in 2VO rats. These results suggest that FA maintains the swallowing reflex by protecting the dopamine-SP system against ischemia-induced oxidative damage in 2VO rats.
format Online
Article
Text
id pubmed-5372566
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-53725662017-04-10 Protective Effects of Ferulic Acid against Chronic Cerebral Hypoperfusion-Induced Swallowing Dysfunction in Rats Asano, Takashi Matsuzaki, Hirokazu Iwata, Naohiro Xuan, Meiyan Kamiuchi, Shinya Hibino, Yasuhide Sakamoto, Takeshi Okazaki, Mari Int J Mol Sci Article Ferulic acid (FA), a phenolic phytochemical, has been reported to exert antioxidative and neuroprotective effects. In this study, we investigated the protective effects of FA against the dysfunction of the swallowing reflex induced by ligation of bilateral common carotid arteries (2VO) in rats. In 2VO rats, topical administration of water or citric acid to the pharyngolaryngeal region evoked a diminished number of swallowing events with prolonged latency compared to sham-operated control rats. 2VO rats had an increased level of superoxide anion radical, and decreased dopamine and tyrosine hydroxylase enzyme levels in the striatum, suggesting that 2VO augmented cerebral oxidative stress and impaired the striatal dopaminergic system. Furthermore, substance P (SP) expression in the laryngopharyngeal mucosa, which is believed to be positively regulated by dopaminergic signaling in the basal ganglia, was decreased in 2VO rats. Oral treatment with FA (30 mg/kg) for 3 weeks (from one week before 2VO to two weeks after) improved the swallowing reflex and maintained levels of striatal dopamine and laryngopharyngeal SP expression in 2VO rats. These results suggest that FA maintains the swallowing reflex by protecting the dopamine-SP system against ischemia-induced oxidative damage in 2VO rats. MDPI 2017-03-03 /pmc/articles/PMC5372566/ /pubmed/28273833 http://dx.doi.org/10.3390/ijms18030550 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Asano, Takashi
Matsuzaki, Hirokazu
Iwata, Naohiro
Xuan, Meiyan
Kamiuchi, Shinya
Hibino, Yasuhide
Sakamoto, Takeshi
Okazaki, Mari
Protective Effects of Ferulic Acid against Chronic Cerebral Hypoperfusion-Induced Swallowing Dysfunction in Rats
title Protective Effects of Ferulic Acid against Chronic Cerebral Hypoperfusion-Induced Swallowing Dysfunction in Rats
title_full Protective Effects of Ferulic Acid against Chronic Cerebral Hypoperfusion-Induced Swallowing Dysfunction in Rats
title_fullStr Protective Effects of Ferulic Acid against Chronic Cerebral Hypoperfusion-Induced Swallowing Dysfunction in Rats
title_full_unstemmed Protective Effects of Ferulic Acid against Chronic Cerebral Hypoperfusion-Induced Swallowing Dysfunction in Rats
title_short Protective Effects of Ferulic Acid against Chronic Cerebral Hypoperfusion-Induced Swallowing Dysfunction in Rats
title_sort protective effects of ferulic acid against chronic cerebral hypoperfusion-induced swallowing dysfunction in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372566/
https://www.ncbi.nlm.nih.gov/pubmed/28273833
http://dx.doi.org/10.3390/ijms18030550
work_keys_str_mv AT asanotakashi protectiveeffectsofferulicacidagainstchroniccerebralhypoperfusioninducedswallowingdysfunctioninrats
AT matsuzakihirokazu protectiveeffectsofferulicacidagainstchroniccerebralhypoperfusioninducedswallowingdysfunctioninrats
AT iwatanaohiro protectiveeffectsofferulicacidagainstchroniccerebralhypoperfusioninducedswallowingdysfunctioninrats
AT xuanmeiyan protectiveeffectsofferulicacidagainstchroniccerebralhypoperfusioninducedswallowingdysfunctioninrats
AT kamiuchishinya protectiveeffectsofferulicacidagainstchroniccerebralhypoperfusioninducedswallowingdysfunctioninrats
AT hibinoyasuhide protectiveeffectsofferulicacidagainstchroniccerebralhypoperfusioninducedswallowingdysfunctioninrats
AT sakamototakeshi protectiveeffectsofferulicacidagainstchroniccerebralhypoperfusioninducedswallowingdysfunctioninrats
AT okazakimari protectiveeffectsofferulicacidagainstchroniccerebralhypoperfusioninducedswallowingdysfunctioninrats