Cargando…

AKT2 Blocks Nucleus Translocation of Apoptosis-Inducing Factor (AIF) and Endonuclease G (EndoG) While Promoting Caspase Activation during Cardiac Ischemia

The AKT (protein kinase B, PKB) family has been shown to participate in diverse cellular processes, including apoptosis. Previous studies demonstrated that protein kinase B2 (AKT2(−/−)) mice heart was sensitized to apoptosis in response to ischemic injury. However, little is known about the mechanis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Shuai, Zhao, Xinmei, Xu, Hui, Chen, Fan, Xu, Yitao, Li, Zhe, Sanchis, Daniel, Jin, Liang, Zhang, Yubin, Ye, Junmei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372581/ https://www.ncbi.nlm.nih.gov/pubmed/28272306 http://dx.doi.org/10.3390/ijms18030565

Ejemplares similares

Crystal structure of the EndoG/EndoGI complex: mechanism of EndoG inhibition
por: Loll, Bernhard, et al.
Publicado: (2009)

Caspase-3 feedback loop enhances Bid-induced AIF/endoG and Bak activation in Bax and p53-independent manner
por: Guo, W, et al.
Publicado: (2015)

EndoG Links Bnip3-Induced Mitochondrial Damage and Caspase-Independent DNA Fragmentation in Ischemic Cardiomyocytes
por: Zhang, Jisheng, et al.
Publicado: (2011)

Bid-Induced Release of AIF/EndoG from Mitochondria Causes Apoptosis of Macrophages during Infection with Leptospira interrogans
por: Hu, Wei-Lin, et al.
Publicado: (2017)

Leishmania infantum EndoG Is an Endo/Exo-Nuclease Essential for Parasite Survival
por: Rico, Eva, et al.
Publicado: (2014)

Involvement of the mitochondrial nuclease EndoG in the regulation of cell proliferation through the control of reactive oxygen species
por: Blasco, Natividad, et al.
Publicado: (2020)

Endonuclease G takes part in AIF-mediated caspase-independent apoptosis in Mycobacterium bovis-infected bovine macrophages
por: Benítez-Guzmán, Alejandro, et al.
Publicado: (2018)

Anti-ROR1 scFv-EndoG as a Novel Anti-Cancer Therapeutic Drug
por: Bemani, Peyman, et al.
Publicado: (2018)

TWEAK Affects Keratinocyte G2/M Growth Arrest and Induces Apoptosis through the Translocation of the AIF Protein to the Nucleus
por: Sabour Alaoui, Sanaa, et al.
Publicado: (2012)

OTUD1 Activates Caspase‐Independent and Caspase‐Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation
por: Luo, Qingyu, et al.
Publicado: (2021)

Structure-based domain assignment in Leishmania infantum EndoG: characterization of a pH-dependent regulatory switch and a C-terminal extension that largely dictates DNA substrate preferences
por: Oliva, Cristina, et al.
Publicado: (2017)

MSC-derived exosomes attenuate cell death through suppressing AIF nucleus translocation and enhance cutaneous wound healing
por: Zhao, Guifang, et al.
Publicado: (2020)

Caspase/AIF/apoptosis pathway: a new target of puerarin for diabetes mellitus therapy
por: Liang, Tao, et al.
Publicado: (2019)

Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function
por: McDermott-Roe, Chris, et al.
Publicado: (2011)

Hepatitis B virus surface protein induces sperm dysfunction through the activation of a Bcl2/Bax signaling cascade triggering AIF/Endo G–mediated apoptosis
por: Han, Ting‐Ting, et al.
Publicado: (2021)

Exercise-induced sudden cardiac death is caused by mitochondrio-nuclear translocation of AIF
por: Abdellatif, Mahmoud, et al.
Publicado: (2021)

Expression of AIF and Caspase-3 in New Zealand rabbit with Cervical Spondylosis Myelopathy model
por: Ibrahim, Sabri, et al.
Publicado: (2021)

ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status
por: Barés, Gisel, et al.
Publicado: (2021)

Cardiac hypertrophy: new role for endonuclease G
Publicado: (2011)

Mitochondrial BNIP3 upregulation precedes endonuclease G translocation in hippocampal neuronal death following oxygen-glucose deprivation
por: Zhao, Shen-Ting, et al.
Publicado: (2009)

Cyclophilin D Regulates the Nuclear Translocation of AIF, Cardiac Endothelial Cell Necroptosis and Murine Cardiac Transplant Injury
por: Qamar, Adnan, et al.
Publicado: (2021)

S1-Type Endonuclease 2 in Dedifferentiating Arabidopsis Protoplasts: Translocation to the Nucleus in Senescing Protoplasts Is Associated with De-Glycosylation
por: Givaty-Rapp, Yemima, et al.
Publicado: (2017)

Biallelic Variants in ENDOG Associated with Mitochondrial Myopathy and Multiple mtDNA Deletions
por: Nasca, Alessia, et al.
Publicado: (2022)

Endonuclease G promotes mitochondrial genome cleavage and replication
por: Wiehe, Rahel Stefanie, et al.
Publicado: (2018)

Increased expression of stefin B in the nucleus of T98G astrocytoma cells delays caspase activation
por: Sun, Tao, et al.
Publicado: (2012)

Dimethyl celecoxib sensitizes gastric cancer cells to ABT‐737 via AIF nuclear translocation
por: Zhang, Bo, et al.
Publicado: (2016)

IL-6: A Potential Role in Cardiac Metabolic Homeostasis
por: Xu, Yitao, et al.
Publicado: (2018)

Ethyl Gallate Induces Apoptosis of HL-60 Cells by Promoting the Expression of Caspases-8, -9, -3, Apoptosis-Inducing Factor and Endonuclease G
por: Kim, Woong-Hyun, et al.
Publicado: (2012)

EXOG, a novel paralog of Endonuclease G in higher eukaryotes
por: Cymerman, Iwona A., et al.
Publicado: (2008)

Correction: Endonuclease G promotes mitochondrial genome cleavage and replication
por: Wiehe, Rahel Stefanie, et al.
Publicado: (2018)

Immunology and Genetic of Leishmania infantum: The Role of Endonuclease G in the Apoptosis
por: Azami, Mehdi, et al.
Publicado: (2018)

Nuclear endonuclease G controls cell proliferation in ovarian cancer
por: Choi, Ye Na, et al.
Publicado: (2023)

Insights from the Molecular Modelling and Docking Analysis of AIF-NLS complex to infer Nuclear Translocation of the Protein
por: Srivaths, Akash, et al.
Publicado: (2018)

PAK5-mediated AIF phosphorylation inhibits its nuclear translocation and promotes breast cancer tumorigenesis
por: Xing, Yao, et al.
Publicado: (2021)

Bioturbation by endogeic earthworms facilitates entomopathogenic nematode movement toward herbivore-damaged maize roots
por: Fattore, Sandrine, et al.
Publicado: (2020)

Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin
por: Blasco, Natividad, et al.
Publicado: (2018)

Crystal structure of the novel lesion-specific endonuclease PfuEndoQ from Pyrococcus furiosus
por: Miyazono, Ken-ichi, et al.
Publicado: (2018)

Endonuclease G mediates α-synuclein cytotoxicity during Parkinson’s disease
por: Büttner, Sabrina, et al.
Publicado: (2013)

Structural adaptation of vertebrate endonuclease G for 5-hydroxymethylcytosine recognition and function
por: Vander Zanden, Crystal M, et al.
Publicado: (2020)

Unleashing a novel function of Endonuclease G in mitochondrial genome instability
por: Dahal, Sumedha, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_uek0kopbps6luv9o7a7d050vhi