Systematic Design of Trypsin Cleavage Site Mutated Exendin4-Cysteine 1, an Orally Bioavailable Glucagon-Like Peptide-1 Receptor Agonist

Exendin-4 is a strong therapeutic candidate for the treatment of metabolic syndrome. Related receptor agonist drugs have been on the market since 2005. However, technical limitations and the pain caused by subcutaneous injection have severely limited patient compliance. The goal of the study is to i...

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Detalles Bibliográficos
Autores principales: Sai, Wenbo, Tian, Hong, Yang, Kangmin, Tang, Daoqi, Bao, Jinxiao, Ge, Yang, Song, Xiaoda, Zhang, Yu, Luo, Cheng, Gao, Xiangdong, Yao, Wenbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372594/
https://www.ncbi.nlm.nih.gov/pubmed/28282854
http://dx.doi.org/10.3390/ijms18030578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372594/
https://www.ncbi.nlm.nih.gov/pubmed/28282854
http://dx.doi.org/10.3390/ijms18030578

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