Potential Neuroprotective Effects of Adiponectin in Alzheimer’s Disease

The adipocyte-secreted protein adiponectin (APN) has several protective functions in the peripheral tissues including insulin sensitizing, anti-inflammatory and anti-oxidative effects that may benefit neurodegenerative diseases such as Alzheimer’s disease (AD). In addition, dysregulation of cerebral...

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Detalles Bibliográficos
Autores principales: Ng, Roy Chun-Laam, Chan, Koon-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372608/
https://www.ncbi.nlm.nih.gov/pubmed/28282917
http://dx.doi.org/10.3390/ijms18030592
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author Ng, Roy Chun-Laam
Chan, Koon-Ho
author_facet Ng, Roy Chun-Laam
Chan, Koon-Ho
author_sort Ng, Roy Chun-Laam
collection PubMed
description The adipocyte-secreted protein adiponectin (APN) has several protective functions in the peripheral tissues including insulin sensitizing, anti-inflammatory and anti-oxidative effects that may benefit neurodegenerative diseases such as Alzheimer’s disease (AD). In addition, dysregulation of cerebral insulin sensitivities and signaling activities have been implicated in AD. Emerging insights into the mechanistic roles of adiponectin and AD highlight the potential therapeutic effects for AD through insulin signaling.
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spelling pubmed-53726082017-04-10 Potential Neuroprotective Effects of Adiponectin in Alzheimer’s Disease Ng, Roy Chun-Laam Chan, Koon-Ho Int J Mol Sci Review The adipocyte-secreted protein adiponectin (APN) has several protective functions in the peripheral tissues including insulin sensitizing, anti-inflammatory and anti-oxidative effects that may benefit neurodegenerative diseases such as Alzheimer’s disease (AD). In addition, dysregulation of cerebral insulin sensitivities and signaling activities have been implicated in AD. Emerging insights into the mechanistic roles of adiponectin and AD highlight the potential therapeutic effects for AD through insulin signaling. MDPI 2017-03-09 /pmc/articles/PMC5372608/ /pubmed/28282917 http://dx.doi.org/10.3390/ijms18030592 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ng, Roy Chun-Laam
Chan, Koon-Ho
Potential Neuroprotective Effects of Adiponectin in Alzheimer’s Disease
title Potential Neuroprotective Effects of Adiponectin in Alzheimer’s Disease
title_full Potential Neuroprotective Effects of Adiponectin in Alzheimer’s Disease
title_fullStr Potential Neuroprotective Effects of Adiponectin in Alzheimer’s Disease
title_full_unstemmed Potential Neuroprotective Effects of Adiponectin in Alzheimer’s Disease
title_short Potential Neuroprotective Effects of Adiponectin in Alzheimer’s Disease
title_sort potential neuroprotective effects of adiponectin in alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372608/
https://www.ncbi.nlm.nih.gov/pubmed/28282917
http://dx.doi.org/10.3390/ijms18030592
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