Revisiting the Metabolism and Bioactivation of Ketoconazole in Human and Mouse Using Liquid Chromatography–Mass Spectrometry-Based Metabolomics

Although ketoconazole (KCZ) has been used worldwide for 30 years, its metabolic characteristics are poorly described. Moreover, the hepatotoxicity of KCZ limits its therapeutic use. In this study, we used liquid chromatography–mass spectrometry-based metabolomics to evaluate the metabolic profile of...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Ju-Hyun, Choi, Won-Gu, Lee, Sangkyu, Lee, Hye Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372636/
https://www.ncbi.nlm.nih.gov/pubmed/28335386
http://dx.doi.org/10.3390/ijms18030621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372636/
https://www.ncbi.nlm.nih.gov/pubmed/28335386
http://dx.doi.org/10.3390/ijms18030621

Ejemplares similares