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BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort
Brain-derived neurotrophic factor (BDNF) is involved in numerous cognitive functions including learning and memory. BDNF plays an important role in synaptic plasticity in humans and rats with BDNF shown to be essential for the formation of long-term memories. We previously identified a significant a...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372667/ https://www.ncbi.nlm.nih.gov/pubmed/28304362 http://dx.doi.org/10.3390/ijms18030655 |
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author | Avgan, Nesli Sutherland, Heidi G. Spriggens, Lauren K. Yu, Chieh Ibrahim, Omar Bellis, Claire Haupt, Larisa M. Shum, David H. K. Griffiths, Lyn R. |
author_facet | Avgan, Nesli Sutherland, Heidi G. Spriggens, Lauren K. Yu, Chieh Ibrahim, Omar Bellis, Claire Haupt, Larisa M. Shum, David H. K. Griffiths, Lyn R. |
author_sort | Avgan, Nesli |
collection | PubMed |
description | Brain-derived neurotrophic factor (BDNF) is involved in numerous cognitive functions including learning and memory. BDNF plays an important role in synaptic plasticity in humans and rats with BDNF shown to be essential for the formation of long-term memories. We previously identified a significant association between the BDNF Val66Met polymorphism (rs6265) and long-term visual memory (p-value = 0.003) in a small cohort (n = 181) comprised of healthy individuals who had been phenotyped for various aspects of memory function. In this study, we have extended the cohort to 597 individuals and examined multiple genetic variants across both the BDNF and BDNF-AS genes for association with visual memory performance as assessed by the Wechsler Memory Scale—Fourth Edition subtests Visual Reproduction I and II (VR I and II). VR I assesses immediate visual memory, whereas VR II assesses long-term visual memory. Genetic association analyses were performed for 34 single nucleotide polymorphisms genotyped on Illumina OmniExpress BeadChip arrays with the immediate and long-term visual memory phenotypes. While none of the BDNF and BDNF-AS variants were shown to be significant for immediate visual memory, we found 10 variants (including the Val66Met polymorphism (p-value = 0.006)) that were nominally associated, and three variants (two variants in BDNF and one variant in the BDNF-AS locus) that were significantly associated with long-term visual memory. Our data therefore suggests a potential role for BDNF, and its anti-sense transcript BDNF-AS, in long-term visual memory performance. |
format | Online Article Text |
id | pubmed-5372667 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53726672017-04-10 BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort Avgan, Nesli Sutherland, Heidi G. Spriggens, Lauren K. Yu, Chieh Ibrahim, Omar Bellis, Claire Haupt, Larisa M. Shum, David H. K. Griffiths, Lyn R. Int J Mol Sci Article Brain-derived neurotrophic factor (BDNF) is involved in numerous cognitive functions including learning and memory. BDNF plays an important role in synaptic plasticity in humans and rats with BDNF shown to be essential for the formation of long-term memories. We previously identified a significant association between the BDNF Val66Met polymorphism (rs6265) and long-term visual memory (p-value = 0.003) in a small cohort (n = 181) comprised of healthy individuals who had been phenotyped for various aspects of memory function. In this study, we have extended the cohort to 597 individuals and examined multiple genetic variants across both the BDNF and BDNF-AS genes for association with visual memory performance as assessed by the Wechsler Memory Scale—Fourth Edition subtests Visual Reproduction I and II (VR I and II). VR I assesses immediate visual memory, whereas VR II assesses long-term visual memory. Genetic association analyses were performed for 34 single nucleotide polymorphisms genotyped on Illumina OmniExpress BeadChip arrays with the immediate and long-term visual memory phenotypes. While none of the BDNF and BDNF-AS variants were shown to be significant for immediate visual memory, we found 10 variants (including the Val66Met polymorphism (p-value = 0.006)) that were nominally associated, and three variants (two variants in BDNF and one variant in the BDNF-AS locus) that were significantly associated with long-term visual memory. Our data therefore suggests a potential role for BDNF, and its anti-sense transcript BDNF-AS, in long-term visual memory performance. MDPI 2017-03-17 /pmc/articles/PMC5372667/ /pubmed/28304362 http://dx.doi.org/10.3390/ijms18030655 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Avgan, Nesli Sutherland, Heidi G. Spriggens, Lauren K. Yu, Chieh Ibrahim, Omar Bellis, Claire Haupt, Larisa M. Shum, David H. K. Griffiths, Lyn R. BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort |
title | BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort |
title_full | BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort |
title_fullStr | BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort |
title_full_unstemmed | BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort |
title_short | BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort |
title_sort | bdnf variants may modulate long-term visual memory performance in a healthy cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372667/ https://www.ncbi.nlm.nih.gov/pubmed/28304362 http://dx.doi.org/10.3390/ijms18030655 |
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