Cargando…

BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort

Brain-derived neurotrophic factor (BDNF) is involved in numerous cognitive functions including learning and memory. BDNF plays an important role in synaptic plasticity in humans and rats with BDNF shown to be essential for the formation of long-term memories. We previously identified a significant a...

Descripción completa

Detalles Bibliográficos
Autores principales: Avgan, Nesli, Sutherland, Heidi G., Spriggens, Lauren K., Yu, Chieh, Ibrahim, Omar, Bellis, Claire, Haupt, Larisa M., Shum, David H. K., Griffiths, Lyn R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372667/
https://www.ncbi.nlm.nih.gov/pubmed/28304362
http://dx.doi.org/10.3390/ijms18030655
_version_ 1782518667856052224
author Avgan, Nesli
Sutherland, Heidi G.
Spriggens, Lauren K.
Yu, Chieh
Ibrahim, Omar
Bellis, Claire
Haupt, Larisa M.
Shum, David H. K.
Griffiths, Lyn R.
author_facet Avgan, Nesli
Sutherland, Heidi G.
Spriggens, Lauren K.
Yu, Chieh
Ibrahim, Omar
Bellis, Claire
Haupt, Larisa M.
Shum, David H. K.
Griffiths, Lyn R.
author_sort Avgan, Nesli
collection PubMed
description Brain-derived neurotrophic factor (BDNF) is involved in numerous cognitive functions including learning and memory. BDNF plays an important role in synaptic plasticity in humans and rats with BDNF shown to be essential for the formation of long-term memories. We previously identified a significant association between the BDNF Val66Met polymorphism (rs6265) and long-term visual memory (p-value = 0.003) in a small cohort (n = 181) comprised of healthy individuals who had been phenotyped for various aspects of memory function. In this study, we have extended the cohort to 597 individuals and examined multiple genetic variants across both the BDNF and BDNF-AS genes for association with visual memory performance as assessed by the Wechsler Memory Scale—Fourth Edition subtests Visual Reproduction I and II (VR I and II). VR I assesses immediate visual memory, whereas VR II assesses long-term visual memory. Genetic association analyses were performed for 34 single nucleotide polymorphisms genotyped on Illumina OmniExpress BeadChip arrays with the immediate and long-term visual memory phenotypes. While none of the BDNF and BDNF-AS variants were shown to be significant for immediate visual memory, we found 10 variants (including the Val66Met polymorphism (p-value = 0.006)) that were nominally associated, and three variants (two variants in BDNF and one variant in the BDNF-AS locus) that were significantly associated with long-term visual memory. Our data therefore suggests a potential role for BDNF, and its anti-sense transcript BDNF-AS, in long-term visual memory performance.
format Online
Article
Text
id pubmed-5372667
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-53726672017-04-10 BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort Avgan, Nesli Sutherland, Heidi G. Spriggens, Lauren K. Yu, Chieh Ibrahim, Omar Bellis, Claire Haupt, Larisa M. Shum, David H. K. Griffiths, Lyn R. Int J Mol Sci Article Brain-derived neurotrophic factor (BDNF) is involved in numerous cognitive functions including learning and memory. BDNF plays an important role in synaptic plasticity in humans and rats with BDNF shown to be essential for the formation of long-term memories. We previously identified a significant association between the BDNF Val66Met polymorphism (rs6265) and long-term visual memory (p-value = 0.003) in a small cohort (n = 181) comprised of healthy individuals who had been phenotyped for various aspects of memory function. In this study, we have extended the cohort to 597 individuals and examined multiple genetic variants across both the BDNF and BDNF-AS genes for association with visual memory performance as assessed by the Wechsler Memory Scale—Fourth Edition subtests Visual Reproduction I and II (VR I and II). VR I assesses immediate visual memory, whereas VR II assesses long-term visual memory. Genetic association analyses were performed for 34 single nucleotide polymorphisms genotyped on Illumina OmniExpress BeadChip arrays with the immediate and long-term visual memory phenotypes. While none of the BDNF and BDNF-AS variants were shown to be significant for immediate visual memory, we found 10 variants (including the Val66Met polymorphism (p-value = 0.006)) that were nominally associated, and three variants (two variants in BDNF and one variant in the BDNF-AS locus) that were significantly associated with long-term visual memory. Our data therefore suggests a potential role for BDNF, and its anti-sense transcript BDNF-AS, in long-term visual memory performance. MDPI 2017-03-17 /pmc/articles/PMC5372667/ /pubmed/28304362 http://dx.doi.org/10.3390/ijms18030655 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Avgan, Nesli
Sutherland, Heidi G.
Spriggens, Lauren K.
Yu, Chieh
Ibrahim, Omar
Bellis, Claire
Haupt, Larisa M.
Shum, David H. K.
Griffiths, Lyn R.
BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort
title BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort
title_full BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort
title_fullStr BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort
title_full_unstemmed BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort
title_short BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort
title_sort bdnf variants may modulate long-term visual memory performance in a healthy cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372667/
https://www.ncbi.nlm.nih.gov/pubmed/28304362
http://dx.doi.org/10.3390/ijms18030655
work_keys_str_mv AT avgannesli bdnfvariantsmaymodulatelongtermvisualmemoryperformanceinahealthycohort
AT sutherlandheidig bdnfvariantsmaymodulatelongtermvisualmemoryperformanceinahealthycohort
AT spriggenslaurenk bdnfvariantsmaymodulatelongtermvisualmemoryperformanceinahealthycohort
AT yuchieh bdnfvariantsmaymodulatelongtermvisualmemoryperformanceinahealthycohort
AT ibrahimomar bdnfvariantsmaymodulatelongtermvisualmemoryperformanceinahealthycohort
AT bellisclaire bdnfvariantsmaymodulatelongtermvisualmemoryperformanceinahealthycohort
AT hauptlarisam bdnfvariantsmaymodulatelongtermvisualmemoryperformanceinahealthycohort
AT shumdavidhk bdnfvariantsmaymodulatelongtermvisualmemoryperformanceinahealthycohort
AT griffithslynr bdnfvariantsmaymodulatelongtermvisualmemoryperformanceinahealthycohort