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Role of Pseudouridine Formation by Deg1 for Functionality of Two Glutamine Isoacceptor tRNAs

Loss of Deg1/Pus3 and concomitant elimination of pseudouridine in tRNA at positions 38 and 39 (ψ38/39) was shown to specifically impair the function of tRNA(Gln)(UUG) under conditions of temperature-induced down-regulation of wobble uridine thiolation in budding yeast and is linked to intellectual d...

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Detalles Bibliográficos
Autores principales: Klassen, Roland, Schaffrath, Raffael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372720/
https://www.ncbi.nlm.nih.gov/pubmed/28134782
http://dx.doi.org/10.3390/biom7010008