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Protection of the Queuosine Biosynthesis Enzyme QueF from Irreversible Oxidation by a Conserved Intramolecular Disulfide

QueF enzymes catalyze the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of the nitrile group of 7-cyano-7-deazaguanine (preQ(0)) to 7-aminomethyl-7-deazaguanine (preQ(1)) in the biosynthetic pathway to the tRNA modified nucleoside queuosine. The QueF-catalyzed reaction incl...

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Detalles Bibliográficos
Autores principales:	Mohammad, Adeba, Bon Ramos, Adriana, Lee, Bobby W. K., Cohen, Spencer W., Kiani, Maryam K., Iwata-Reuyl, Dirk, Stec, Boguslaw, Swairjo, Manal A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372742/ https://www.ncbi.nlm.nih.gov/pubmed/28300774 http://dx.doi.org/10.3390/biom7010030

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