Cargando…

Interaction between Single Nucleotide Polymorphism and Urinary Sodium, Potassium, and Sodium-Potassium Ratio on the Risk of Hypertension in Korean Adults

Hypertension is a complex disease explained with diverse factors including environmental factors and genetic factors. The objectives of this study were to determine the interaction effects between gene variants and 24 h estimated urinary sodium and potassium excretion and sodium-potassium excretion...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Yeong Mi, Kwock, Chang Keun, Kim, Kyunga, Kim, Jihye, Yang, Yoon Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372898/
https://www.ncbi.nlm.nih.gov/pubmed/28273873
http://dx.doi.org/10.3390/nu9030235
_version_ 1782518713671483392
author Park, Yeong Mi
Kwock, Chang Keun
Kim, Kyunga
Kim, Jihye
Yang, Yoon Jung
author_facet Park, Yeong Mi
Kwock, Chang Keun
Kim, Kyunga
Kim, Jihye
Yang, Yoon Jung
author_sort Park, Yeong Mi
collection PubMed
description Hypertension is a complex disease explained with diverse factors including environmental factors and genetic factors. The objectives of this study were to determine the interaction effects between gene variants and 24 h estimated urinary sodium and potassium excretion and sodium-potassium excretion ratios on the risk of hypertension. A total of 8839 participants were included in the genome-wide association study (GWAS) to find genetic factors associated with hypertension. Tanaka and Kawasaki formulas were applied to estimate 24 h urinary sodium and potassium excretion. A total of 4414 participants were included in interaction analyses to identify the interaction effects of gene variants according to 24 h estimated urinary factors on the risk of hypertension. CSK rs1378942 and CSK-MIR4513 rs3784789 were significantly modified by urinary sodium-potassium excretion ratio. In addition, MKLN rs1643270 with urinary potassium excretion, LOC101929750 rs7554672 with urinary sodium and potassium excretion, and TENM4 rs10466739 with urinary sodium-potassium excretion ratio showed significant interaction effects. The present study results indicated that the mutant alleles of CSK rs1378942 and CSK-MIR4513 rs3784789 had the strongest protective effects against hypertension in the middle group of 24 h estimated urinary sodium-potassium excretion ratio. Further studies are needed to replicate these analyses in other populations.
format Online
Article
Text
id pubmed-5372898
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-53728982017-04-05 Interaction between Single Nucleotide Polymorphism and Urinary Sodium, Potassium, and Sodium-Potassium Ratio on the Risk of Hypertension in Korean Adults Park, Yeong Mi Kwock, Chang Keun Kim, Kyunga Kim, Jihye Yang, Yoon Jung Nutrients Article Hypertension is a complex disease explained with diverse factors including environmental factors and genetic factors. The objectives of this study were to determine the interaction effects between gene variants and 24 h estimated urinary sodium and potassium excretion and sodium-potassium excretion ratios on the risk of hypertension. A total of 8839 participants were included in the genome-wide association study (GWAS) to find genetic factors associated with hypertension. Tanaka and Kawasaki formulas were applied to estimate 24 h urinary sodium and potassium excretion. A total of 4414 participants were included in interaction analyses to identify the interaction effects of gene variants according to 24 h estimated urinary factors on the risk of hypertension. CSK rs1378942 and CSK-MIR4513 rs3784789 were significantly modified by urinary sodium-potassium excretion ratio. In addition, MKLN rs1643270 with urinary potassium excretion, LOC101929750 rs7554672 with urinary sodium and potassium excretion, and TENM4 rs10466739 with urinary sodium-potassium excretion ratio showed significant interaction effects. The present study results indicated that the mutant alleles of CSK rs1378942 and CSK-MIR4513 rs3784789 had the strongest protective effects against hypertension in the middle group of 24 h estimated urinary sodium-potassium excretion ratio. Further studies are needed to replicate these analyses in other populations. MDPI 2017-03-05 /pmc/articles/PMC5372898/ /pubmed/28273873 http://dx.doi.org/10.3390/nu9030235 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Park, Yeong Mi
Kwock, Chang Keun
Kim, Kyunga
Kim, Jihye
Yang, Yoon Jung
Interaction between Single Nucleotide Polymorphism and Urinary Sodium, Potassium, and Sodium-Potassium Ratio on the Risk of Hypertension in Korean Adults
title Interaction between Single Nucleotide Polymorphism and Urinary Sodium, Potassium, and Sodium-Potassium Ratio on the Risk of Hypertension in Korean Adults
title_full Interaction between Single Nucleotide Polymorphism and Urinary Sodium, Potassium, and Sodium-Potassium Ratio on the Risk of Hypertension in Korean Adults
title_fullStr Interaction between Single Nucleotide Polymorphism and Urinary Sodium, Potassium, and Sodium-Potassium Ratio on the Risk of Hypertension in Korean Adults
title_full_unstemmed Interaction between Single Nucleotide Polymorphism and Urinary Sodium, Potassium, and Sodium-Potassium Ratio on the Risk of Hypertension in Korean Adults
title_short Interaction between Single Nucleotide Polymorphism and Urinary Sodium, Potassium, and Sodium-Potassium Ratio on the Risk of Hypertension in Korean Adults
title_sort interaction between single nucleotide polymorphism and urinary sodium, potassium, and sodium-potassium ratio on the risk of hypertension in korean adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372898/
https://www.ncbi.nlm.nih.gov/pubmed/28273873
http://dx.doi.org/10.3390/nu9030235
work_keys_str_mv AT parkyeongmi interactionbetweensinglenucleotidepolymorphismandurinarysodiumpotassiumandsodiumpotassiumratioontheriskofhypertensioninkoreanadults
AT kwockchangkeun interactionbetweensinglenucleotidepolymorphismandurinarysodiumpotassiumandsodiumpotassiumratioontheriskofhypertensioninkoreanadults
AT kimkyunga interactionbetweensinglenucleotidepolymorphismandurinarysodiumpotassiumandsodiumpotassiumratioontheriskofhypertensioninkoreanadults
AT kimjihye interactionbetweensinglenucleotidepolymorphismandurinarysodiumpotassiumandsodiumpotassiumratioontheriskofhypertensioninkoreanadults
AT yangyoonjung interactionbetweensinglenucleotidepolymorphismandurinarysodiumpotassiumandsodiumpotassiumratioontheriskofhypertensioninkoreanadults