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Docking into Mycobacterium tuberculosis Thioredoxin Reductase Protein Yields Pyrazolone Lead Molecules for Methicillin-Resistant Staphylococcus aureus

The thioredoxin/thioredoxin reductase system (Trx/TrxR) is an attractive drug target because of its involvement in a number of important physiological processes, from DNA synthesis to regulating signal transduction. This study describes the finding of pyrazolone compounds that are active against Sta...

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Detalles Bibliográficos
Autores principales:	Sweeney, Noreena L., Lipker, Lauren, Hanson, Alicia M., Bohl, Chris J., Engel, Katie E., Kalous, Kelsey S., Stemper, Mary E., Sem, Daniel S., Schwan, William R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372984/ https://www.ncbi.nlm.nih.gov/pubmed/28134858 http://dx.doi.org/10.3390/antibiotics6010004

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