Genetically engineered rat gliomas: PDGF-driven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer

Previously rodent preclinical research in gliomas frequently involved implantation of cell lines such as C6 and 9L into the rat brain. More recently, mouse models have taken over, the genetic manipulability of the mouse allowing the creation of genetically accurate models outweighed the disadvantage...

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Detalles Bibliográficos
Autores principales: Connolly, Nina P., Stokum, Jesse A., Schneider, Craig S., Ozawa, Tatsuya, Xu, Su, Galisteo, Rebeca, Castellani, Rudolph J., Kim, Anthony J., Simard, J. Marc, Winkles, Jeffrey A., Holland, Eric C., Woodworth, Graeme F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373526/
https://www.ncbi.nlm.nih.gov/pubmed/28358926
http://dx.doi.org/10.1371/journal.pone.0174557

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