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Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS

Progranulin (PGRN) is a glycoprotein with multiple roles in normal and disease states. Mutations within the GRN gene cause frontotemporal lobar degeneration (FTLD). The affected neurons display distinctive TAR DNA binding protein 43 (TDP-43) inclusions. How partial loss of PGRN causes TDP-43 neuropa...

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Detalles Bibliográficos
Autores principales:	Chitramuthu, Babykumari P., Kay, Denis G., Bateman, Andrew, Bennett, Hugh P. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373598/ https://www.ncbi.nlm.nih.gov/pubmed/28358904 http://dx.doi.org/10.1371/journal.pone.0174784

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