Cargando…

Dynamic abnormalities of spontaneous brain activity in women with primary dysmenorrhea

PURPOSE: This study aimed to investigate the regional spontaneous brain activity changes in primary dysmenorrhea (PD) patients in different phases of the menstrual cycle by regional homogeneity (ReHo) analysis. PATIENTS AND METHODS: Thirty-three PD patients and 32 healthy controls (HCs) separately r...

Descripción completa

Detalles Bibliográficos
Autores principales: Jin, Lingmin, Yang, Xuejuan, Liu, Peng, Sun, Jinbo, Chen, Fei, Xu, Ziliang, Qin, Wei, Tian, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373826/
https://www.ncbi.nlm.nih.gov/pubmed/28392711
http://dx.doi.org/10.2147/JPR.S121286
_version_ 1782518813621747712
author Jin, Lingmin
Yang, Xuejuan
Liu, Peng
Sun, Jinbo
Chen, Fei
Xu, Ziliang
Qin, Wei
Tian, Jie
author_facet Jin, Lingmin
Yang, Xuejuan
Liu, Peng
Sun, Jinbo
Chen, Fei
Xu, Ziliang
Qin, Wei
Tian, Jie
author_sort Jin, Lingmin
collection PubMed
description PURPOSE: This study aimed to investigate the regional spontaneous brain activity changes in primary dysmenorrhea (PD) patients in different phases of the menstrual cycle by regional homogeneity (ReHo) analysis. PATIENTS AND METHODS: Thirty-three PD patients and 32 healthy controls (HCs) separately received resting-state functional magnetic resonance imaging during menstrual phase and follicular phase (non-menstrual phase). Cox retrospective symptom scale (RSS), Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were applied to assess related symptoms and emotions. RESULTS: There was no significant difference between the two groups in demographic data. The PD patients obtained higher RSS score, SAS score and SDS score than HCs. Compared with HCs, the ReHo values of the PD patients were increased in left midbrain and hippocampus, right posterior cingulate cortex (PCC), insula and middle temporal cortex (MTC) and decreased in left dorsolateral prefrontal cortex and right medial prefrontal cortex (mPFC) in menstrual phase. In non-menstrual phase, enhanced ReHo values were found in bilateral S1 and precuneus, left S2 and MTC, and reduced ReHo values were observed in left mPFC and orbital frontal cortex. RSS score positively correlated with ReHo values of midbrain and negatively correlated with mPFC and PCC. CONCLUSION: Our results suggested that PD is accompanied by dynamic regional spontaneous activity changes across the menstrual cycle, and the altered regions were involved in descending pain modulation, default mode network and sensory modulation. These abnormal activations might contribute to maintain the menstrual pain.
format Online
Article
Text
id pubmed-5373826
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-53738262017-04-07 Dynamic abnormalities of spontaneous brain activity in women with primary dysmenorrhea Jin, Lingmin Yang, Xuejuan Liu, Peng Sun, Jinbo Chen, Fei Xu, Ziliang Qin, Wei Tian, Jie J Pain Res Original Research PURPOSE: This study aimed to investigate the regional spontaneous brain activity changes in primary dysmenorrhea (PD) patients in different phases of the menstrual cycle by regional homogeneity (ReHo) analysis. PATIENTS AND METHODS: Thirty-three PD patients and 32 healthy controls (HCs) separately received resting-state functional magnetic resonance imaging during menstrual phase and follicular phase (non-menstrual phase). Cox retrospective symptom scale (RSS), Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were applied to assess related symptoms and emotions. RESULTS: There was no significant difference between the two groups in demographic data. The PD patients obtained higher RSS score, SAS score and SDS score than HCs. Compared with HCs, the ReHo values of the PD patients were increased in left midbrain and hippocampus, right posterior cingulate cortex (PCC), insula and middle temporal cortex (MTC) and decreased in left dorsolateral prefrontal cortex and right medial prefrontal cortex (mPFC) in menstrual phase. In non-menstrual phase, enhanced ReHo values were found in bilateral S1 and precuneus, left S2 and MTC, and reduced ReHo values were observed in left mPFC and orbital frontal cortex. RSS score positively correlated with ReHo values of midbrain and negatively correlated with mPFC and PCC. CONCLUSION: Our results suggested that PD is accompanied by dynamic regional spontaneous activity changes across the menstrual cycle, and the altered regions were involved in descending pain modulation, default mode network and sensory modulation. These abnormal activations might contribute to maintain the menstrual pain. Dove Medical Press 2017-03-24 /pmc/articles/PMC5373826/ /pubmed/28392711 http://dx.doi.org/10.2147/JPR.S121286 Text en © 2017 Jin et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Jin, Lingmin
Yang, Xuejuan
Liu, Peng
Sun, Jinbo
Chen, Fei
Xu, Ziliang
Qin, Wei
Tian, Jie
Dynamic abnormalities of spontaneous brain activity in women with primary dysmenorrhea
title Dynamic abnormalities of spontaneous brain activity in women with primary dysmenorrhea
title_full Dynamic abnormalities of spontaneous brain activity in women with primary dysmenorrhea
title_fullStr Dynamic abnormalities of spontaneous brain activity in women with primary dysmenorrhea
title_full_unstemmed Dynamic abnormalities of spontaneous brain activity in women with primary dysmenorrhea
title_short Dynamic abnormalities of spontaneous brain activity in women with primary dysmenorrhea
title_sort dynamic abnormalities of spontaneous brain activity in women with primary dysmenorrhea
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373826/
https://www.ncbi.nlm.nih.gov/pubmed/28392711
http://dx.doi.org/10.2147/JPR.S121286
work_keys_str_mv AT jinlingmin dynamicabnormalitiesofspontaneousbrainactivityinwomenwithprimarydysmenorrhea
AT yangxuejuan dynamicabnormalitiesofspontaneousbrainactivityinwomenwithprimarydysmenorrhea
AT liupeng dynamicabnormalitiesofspontaneousbrainactivityinwomenwithprimarydysmenorrhea
AT sunjinbo dynamicabnormalitiesofspontaneousbrainactivityinwomenwithprimarydysmenorrhea
AT chenfei dynamicabnormalitiesofspontaneousbrainactivityinwomenwithprimarydysmenorrhea
AT xuziliang dynamicabnormalitiesofspontaneousbrainactivityinwomenwithprimarydysmenorrhea
AT qinwei dynamicabnormalitiesofspontaneousbrainactivityinwomenwithprimarydysmenorrhea
AT tianjie dynamicabnormalitiesofspontaneousbrainactivityinwomenwithprimarydysmenorrhea