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Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning
Drugs of abuse alter synaptic connections in the ‘reward circuit’ of the brain, which leads to long-lasting behavioral changes that underlie addiction. Here we show that cadherin adhesion molecules play a critical role in mediating synaptic plasticity and behavioral changes driven by cocaine. We dem...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373847/ https://www.ncbi.nlm.nih.gov/pubmed/28192395 http://dx.doi.org/10.1038/nn.4503 |
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author | Mills, Fergil Globa, Andrea K. Liu, Shuai Cowan, Catherine M. Mobasser, Mahsan Phillips, Anthony G. Borgland, Stephanie L. Bamji, Shernaz X. |
author_facet | Mills, Fergil Globa, Andrea K. Liu, Shuai Cowan, Catherine M. Mobasser, Mahsan Phillips, Anthony G. Borgland, Stephanie L. Bamji, Shernaz X. |
author_sort | Mills, Fergil |
collection | PubMed |
description | Drugs of abuse alter synaptic connections in the ‘reward circuit’ of the brain, which leads to long-lasting behavioral changes that underlie addiction. Here we show that cadherin adhesion molecules play a critical role in mediating synaptic plasticity and behavioral changes driven by cocaine. We demonstrate that cadherin is essential for long-term potentiation (LTP) in the ventral tegmental area (VTA), and is recruited to the synaptic membrane of excitatory inputs onto dopaminergic neurons following cocaine-mediated behavioral conditioning. Furthermore, we show that stabilization of cadherin at the membrane of these synapses blocks cocaine-induced synaptic plasticity, leading to a significant reduction in conditioned place preference induced by cocaine. Our findings identify cadherins and associated molecules as targets of interest for understanding pathological plasticity associated with addiction. |
format | Online Article Text |
id | pubmed-5373847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
record_format | MEDLINE/PubMed |
spelling | pubmed-53738472017-10-01 Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning Mills, Fergil Globa, Andrea K. Liu, Shuai Cowan, Catherine M. Mobasser, Mahsan Phillips, Anthony G. Borgland, Stephanie L. Bamji, Shernaz X. Nat Neurosci Article Drugs of abuse alter synaptic connections in the ‘reward circuit’ of the brain, which leads to long-lasting behavioral changes that underlie addiction. Here we show that cadherin adhesion molecules play a critical role in mediating synaptic plasticity and behavioral changes driven by cocaine. We demonstrate that cadherin is essential for long-term potentiation (LTP) in the ventral tegmental area (VTA), and is recruited to the synaptic membrane of excitatory inputs onto dopaminergic neurons following cocaine-mediated behavioral conditioning. Furthermore, we show that stabilization of cadherin at the membrane of these synapses blocks cocaine-induced synaptic plasticity, leading to a significant reduction in conditioned place preference induced by cocaine. Our findings identify cadherins and associated molecules as targets of interest for understanding pathological plasticity associated with addiction. 2017-02-13 2017-04 /pmc/articles/PMC5373847/ /pubmed/28192395 http://dx.doi.org/10.1038/nn.4503 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Mills, Fergil Globa, Andrea K. Liu, Shuai Cowan, Catherine M. Mobasser, Mahsan Phillips, Anthony G. Borgland, Stephanie L. Bamji, Shernaz X. Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning |
title | Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning |
title_full | Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning |
title_fullStr | Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning |
title_full_unstemmed | Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning |
title_short | Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning |
title_sort | cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373847/ https://www.ncbi.nlm.nih.gov/pubmed/28192395 http://dx.doi.org/10.1038/nn.4503 |
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