MDM2 but not MDM4 promotes retinoblastoma cell proliferation through p53-independent regulation of MYCN translation

Retinoblastomas can arise from cone photoreceptor precursors in response to the loss of pRB function. Cone precursor-specific circuitry cooperates with pRB loss to initiate this process and subsequently contributes to the malignancy. Intrinsic high level MDM2 expression is a key component of the con...

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Detalles Bibliográficos
Autores principales: Qi, Dong-Lai, Cobrinik, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374018/
https://www.ncbi.nlm.nih.gov/pubmed/27748758
http://dx.doi.org/10.1038/onc.2016.350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374018/
https://www.ncbi.nlm.nih.gov/pubmed/27748758
http://dx.doi.org/10.1038/onc.2016.350

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