Design and Biological Evaluation of Delivery Systems Containing Bisphosphonates

Bisphosphonates have found application in the treatment of reoccurrence of bone diseases, breast cancer, etc. They have also been found to exhibit antimicrobial, anticancer and antimalarial activities. However, they suffer from pharmacological deficiencies such as toxicity, poor bioavailability and...

Descripción completa

Detalles Bibliográficos
Autores principales: Aderibigbe, Blessing, Aderibigbe, Isiaka, Popoola, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374368/
https://www.ncbi.nlm.nih.gov/pubmed/28035945
http://dx.doi.org/10.3390/pharmaceutics9010002
_version_ 1782518874877460480
author Aderibigbe, Blessing
Aderibigbe, Isiaka
Popoola, Patricia
author_facet Aderibigbe, Blessing
Aderibigbe, Isiaka
Popoola, Patricia
author_sort Aderibigbe, Blessing
collection PubMed
description Bisphosphonates have found application in the treatment of reoccurrence of bone diseases, breast cancer, etc. They have also been found to exhibit antimicrobial, anticancer and antimalarial activities. However, they suffer from pharmacological deficiencies such as toxicity, poor bioavailability and low intestinal adsorption. These shortcomings have resulted in several researchers developing delivery systems that can enhance their overall therapeutic effectiveness. This review provides a detailed overview of the published studies on delivery systems designed for the delivery of bisphosphonates and the corresponding in vitro/in vivo results.
format Online
Article
Text
id pubmed-5374368
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-53743682017-04-10 Design and Biological Evaluation of Delivery Systems Containing Bisphosphonates Aderibigbe, Blessing Aderibigbe, Isiaka Popoola, Patricia Pharmaceutics Review Bisphosphonates have found application in the treatment of reoccurrence of bone diseases, breast cancer, etc. They have also been found to exhibit antimicrobial, anticancer and antimalarial activities. However, they suffer from pharmacological deficiencies such as toxicity, poor bioavailability and low intestinal adsorption. These shortcomings have resulted in several researchers developing delivery systems that can enhance their overall therapeutic effectiveness. This review provides a detailed overview of the published studies on delivery systems designed for the delivery of bisphosphonates and the corresponding in vitro/in vivo results. MDPI 2016-12-26 /pmc/articles/PMC5374368/ /pubmed/28035945 http://dx.doi.org/10.3390/pharmaceutics9010002 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Aderibigbe, Blessing
Aderibigbe, Isiaka
Popoola, Patricia
Design and Biological Evaluation of Delivery Systems Containing Bisphosphonates
title Design and Biological Evaluation of Delivery Systems Containing Bisphosphonates
title_full Design and Biological Evaluation of Delivery Systems Containing Bisphosphonates
title_fullStr Design and Biological Evaluation of Delivery Systems Containing Bisphosphonates
title_full_unstemmed Design and Biological Evaluation of Delivery Systems Containing Bisphosphonates
title_short Design and Biological Evaluation of Delivery Systems Containing Bisphosphonates
title_sort design and biological evaluation of delivery systems containing bisphosphonates
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374368/
https://www.ncbi.nlm.nih.gov/pubmed/28035945
http://dx.doi.org/10.3390/pharmaceutics9010002
work_keys_str_mv AT aderibigbeblessing designandbiologicalevaluationofdeliverysystemscontainingbisphosphonates
AT aderibigbeisiaka designandbiologicalevaluationofdeliverysystemscontainingbisphosphonates
AT popoolapatricia designandbiologicalevaluationofdeliverysystemscontainingbisphosphonates

Ejemplares similares