Lobular Distribution and Variability in Hepatic ATP Binding Cassette Protein B1 (ABCB1, P-gp): Ontogenetic Differences and Potential for Toxicity

The ATP Binding Cassette B1 (ABCB1) transporter has critical roles in endo- and xenobiotic efficacy and toxicity. To understand population variability in hepatic transport we determined ABCB1 mRNA and protein levels in total liver lysates sampled from 8 pre-defined sites (n = 24, 18–69 years), and i...

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Detalles Bibliográficos
Autores principales: Abanda, Ngu Njei, Riches, Zoe, Collier, Abby C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374374/
https://www.ncbi.nlm.nih.gov/pubmed/28218636
http://dx.doi.org/10.3390/pharmaceutics9010008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374374/
https://www.ncbi.nlm.nih.gov/pubmed/28218636
http://dx.doi.org/10.3390/pharmaceutics9010008

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