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Improving the accuracy of high-throughput protein-protein affinity prediction may require better training data

BACKGROUND: One goal of structural biology is to understand how a protein’s 3-dimensional conformation determines its capacity to interact with potential ligands. In the case of small chemical ligands, deconstructing a static protein-ligand complex into its constituent atom-atom interactions is typi...

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Detalles Bibliográficos
Autores principales:	Dias, Raquel, Kolaczkowski, Bryan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374557/ https://www.ncbi.nlm.nih.gov/pubmed/28361672 http://dx.doi.org/10.1186/s12859-017-1533-z

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