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Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism

BACKGROUND: Recent investigations suggest role(s) of human arylamine N-acetyltransferase 1 (NAT1) in breast cancer. Rat NAT2 is orthologous to human NAT1 and the gene products are functional homologs. We conducted in vivo studies using F344.WKY-Nat2 (rapid/slow) rats, congenic at rat Nat2 for high (...

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Detalles Bibliográficos
Autores principales:	Stepp, Marcus W., Doll, Mark A., Samuelson, David J., Sanders, Mary Ann G., States, J. Christopher, Hein, David W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374573/ https://www.ncbi.nlm.nih.gov/pubmed/28359264 http://dx.doi.org/10.1186/s12885-017-3221-9

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