The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander disease

Rosenthal fibers (RFs) are cytoplasmic, proteinaceous aggregates. They are the pathognomonic feature of the astrocyte pathology in Alexander Disease (AxD), a neurodegenerative disorder caused by heterozygous mutations in the GFAP gene, encoding glial fibrillary acidic protein (GFAP). Although RFs ha...

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Detalles Bibliográficos
Autores principales: Sosunov, Alexander A., McKhann, Guy M., Goldman, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374671/
https://www.ncbi.nlm.nih.gov/pubmed/28359321
http://dx.doi.org/10.1186/s40478-017-0425-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374671/
https://www.ncbi.nlm.nih.gov/pubmed/28359321
http://dx.doi.org/10.1186/s40478-017-0425-9

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