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Receptor-guided 3D-QSAR studies, molecular dynamics simulation and free energy calculations of Btk kinase inhibitors

BACKGROUND: Bruton tyrosine kinase (Btk) plays an important role in B-cell development, differentiation, and signaling. It is also found be in involved in male immunodeficiency disease such as X-linked agammaglobulinemia (XLA). Btk is considered as a potential therapeutic target for treating autoimm...

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Detalles Bibliográficos
Autores principales:	Balasubramanian, Pavithra K., Balupuri, Anand, Kang, Hee-Young, Cho, Seung Joo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374705/ https://www.ncbi.nlm.nih.gov/pubmed/28361711 http://dx.doi.org/10.1186/s12918-017-0385-5

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