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iPS cell technologies and their prospect for bone regeneration and disease modeling: A mini review

Bone disorders are a group of varied acute and chronic traumatic, degenerative, malignant or congenital conditions affecting the musculoskeletal system. They are prevalent in society and, with an ageing population, the incidence and impact on the population’s health is growing. Severe persisting pai...

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Detalles Bibliográficos
Autores principales: Csobonyeiova, Maria, Polak, Stefan, Zamborsky, Radoslav, Danisovic, Lubos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374850/
https://www.ncbi.nlm.nih.gov/pubmed/28386481
http://dx.doi.org/10.1016/j.jare.2017.02.004
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author Csobonyeiova, Maria
Polak, Stefan
Zamborsky, Radoslav
Danisovic, Lubos
author_facet Csobonyeiova, Maria
Polak, Stefan
Zamborsky, Radoslav
Danisovic, Lubos
author_sort Csobonyeiova, Maria
collection PubMed
description Bone disorders are a group of varied acute and chronic traumatic, degenerative, malignant or congenital conditions affecting the musculoskeletal system. They are prevalent in society and, with an ageing population, the incidence and impact on the population’s health is growing. Severe persisting pain and limited mobility are the major symptoms of the disorder that impair the quality of life in affected patients. Current therapies only partially treat the disorders, offering management of symptoms, or temporary replacement with inert materials. However, during the last few years, the options for the treatment of bone disorders have greatly expanded, thanks to the advent of regenerative medicine. Skeletal cell-based regeneration medicine offers promising reparative therapies for patients. Mesenchymal stem (stromal) cells from different tissues have been gradually translated into clinical practice; however, there are a number of limitations. The introduction of reprogramming methods and the subsequent production of induced pluripotent stem cells provides a possibility to create human-specific models of bone disorders. Furthermore, human-induced pluripotent stem cell-based autologous transplantation is considered to be future breakthrough in the field of regenerative medicine. The main goal of the present paper is to review recent applications of induced pluripotent stem cells in bone disease modeling and to discuss possible future therapy options. The present article contributes to the dissemination of scientific and pre-clinical results between physicians, mainly orthopedist and thus supports the translation to clinical practice.
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spelling pubmed-53748502017-04-06 iPS cell technologies and their prospect for bone regeneration and disease modeling: A mini review Csobonyeiova, Maria Polak, Stefan Zamborsky, Radoslav Danisovic, Lubos J Adv Res Mini Review Bone disorders are a group of varied acute and chronic traumatic, degenerative, malignant or congenital conditions affecting the musculoskeletal system. They are prevalent in society and, with an ageing population, the incidence and impact on the population’s health is growing. Severe persisting pain and limited mobility are the major symptoms of the disorder that impair the quality of life in affected patients. Current therapies only partially treat the disorders, offering management of symptoms, or temporary replacement with inert materials. However, during the last few years, the options for the treatment of bone disorders have greatly expanded, thanks to the advent of regenerative medicine. Skeletal cell-based regeneration medicine offers promising reparative therapies for patients. Mesenchymal stem (stromal) cells from different tissues have been gradually translated into clinical practice; however, there are a number of limitations. The introduction of reprogramming methods and the subsequent production of induced pluripotent stem cells provides a possibility to create human-specific models of bone disorders. Furthermore, human-induced pluripotent stem cell-based autologous transplantation is considered to be future breakthrough in the field of regenerative medicine. The main goal of the present paper is to review recent applications of induced pluripotent stem cells in bone disease modeling and to discuss possible future therapy options. The present article contributes to the dissemination of scientific and pre-clinical results between physicians, mainly orthopedist and thus supports the translation to clinical practice. Elsevier 2017-07 2017-03-06 /pmc/articles/PMC5374850/ /pubmed/28386481 http://dx.doi.org/10.1016/j.jare.2017.02.004 Text en © 2017 Production and hosting by Elsevier B.V. on behalf of Cairo University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Mini Review
Csobonyeiova, Maria
Polak, Stefan
Zamborsky, Radoslav
Danisovic, Lubos
iPS cell technologies and their prospect for bone regeneration and disease modeling: A mini review
title iPS cell technologies and their prospect for bone regeneration and disease modeling: A mini review
title_full iPS cell technologies and their prospect for bone regeneration and disease modeling: A mini review
title_fullStr iPS cell technologies and their prospect for bone regeneration and disease modeling: A mini review
title_full_unstemmed iPS cell technologies and their prospect for bone regeneration and disease modeling: A mini review
title_short iPS cell technologies and their prospect for bone regeneration and disease modeling: A mini review
title_sort ips cell technologies and their prospect for bone regeneration and disease modeling: a mini review
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374850/
https://www.ncbi.nlm.nih.gov/pubmed/28386481
http://dx.doi.org/10.1016/j.jare.2017.02.004
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