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A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging

The development of low profile gamma-ray detectors has encouraged the production of small field of view (SFOV) hand-held imaging devices for use at the patient bedside and in operating theatres. Early development of these SFOV cameras was focussed on a single modality—gamma ray imaging. Recently, a...

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Autores principales: Lees, John E., Bugby, Sarah L., Alqahtani, Mohammed S., Jambi, Layal K., Dawood, Numan S., McKnight, William R., Ng, Aik H., Perkins, Alan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5375840/
https://www.ncbi.nlm.nih.gov/pubmed/28282957
http://dx.doi.org/10.3390/s17030554
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author Lees, John E.
Bugby, Sarah L.
Alqahtani, Mohammed S.
Jambi, Layal K.
Dawood, Numan S.
McKnight, William R.
Ng, Aik H.
Perkins, Alan C.
author_facet Lees, John E.
Bugby, Sarah L.
Alqahtani, Mohammed S.
Jambi, Layal K.
Dawood, Numan S.
McKnight, William R.
Ng, Aik H.
Perkins, Alan C.
author_sort Lees, John E.
collection PubMed
description The development of low profile gamma-ray detectors has encouraged the production of small field of view (SFOV) hand-held imaging devices for use at the patient bedside and in operating theatres. Early development of these SFOV cameras was focussed on a single modality—gamma ray imaging. Recently, a hybrid system—gamma plus optical imaging—has been developed. This combination of optical and gamma cameras enables high spatial resolution multi-modal imaging, giving a superimposed scintigraphic and optical image. Hybrid imaging offers new possibilities for assisting clinicians and surgeons in localising the site of uptake in procedures such as sentinel node detection. The hybrid camera concept can be extended to a multimodal detector design which can offer stereoscopic images, depth estimation of gamma-emitting sources, and simultaneous gamma and fluorescence imaging. Recent improvements to the hybrid camera have been used to produce dual-modality images in both laboratory simulations and in the clinic. Hybrid imaging of a patient who underwent thyroid scintigraphy is reported. In addition, we present data which shows that the hybrid camera concept can be extended to estimate the position and depth of radionuclide distribution within an object and also report the first combined gamma and Near-Infrared (NIR) fluorescence images.
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spelling pubmed-53758402017-04-10 A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging Lees, John E. Bugby, Sarah L. Alqahtani, Mohammed S. Jambi, Layal K. Dawood, Numan S. McKnight, William R. Ng, Aik H. Perkins, Alan C. Sensors (Basel) Article The development of low profile gamma-ray detectors has encouraged the production of small field of view (SFOV) hand-held imaging devices for use at the patient bedside and in operating theatres. Early development of these SFOV cameras was focussed on a single modality—gamma ray imaging. Recently, a hybrid system—gamma plus optical imaging—has been developed. This combination of optical and gamma cameras enables high spatial resolution multi-modal imaging, giving a superimposed scintigraphic and optical image. Hybrid imaging offers new possibilities for assisting clinicians and surgeons in localising the site of uptake in procedures such as sentinel node detection. The hybrid camera concept can be extended to a multimodal detector design which can offer stereoscopic images, depth estimation of gamma-emitting sources, and simultaneous gamma and fluorescence imaging. Recent improvements to the hybrid camera have been used to produce dual-modality images in both laboratory simulations and in the clinic. Hybrid imaging of a patient who underwent thyroid scintigraphy is reported. In addition, we present data which shows that the hybrid camera concept can be extended to estimate the position and depth of radionuclide distribution within an object and also report the first combined gamma and Near-Infrared (NIR) fluorescence images. MDPI 2017-03-09 /pmc/articles/PMC5375840/ /pubmed/28282957 http://dx.doi.org/10.3390/s17030554 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lees, John E.
Bugby, Sarah L.
Alqahtani, Mohammed S.
Jambi, Layal K.
Dawood, Numan S.
McKnight, William R.
Ng, Aik H.
Perkins, Alan C.
A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging
title A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging
title_full A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging
title_fullStr A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging
title_full_unstemmed A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging
title_short A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging
title_sort multimodality hybrid gamma-optical camera for intraoperative imaging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5375840/
https://www.ncbi.nlm.nih.gov/pubmed/28282957
http://dx.doi.org/10.3390/s17030554
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