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A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging
The development of low profile gamma-ray detectors has encouraged the production of small field of view (SFOV) hand-held imaging devices for use at the patient bedside and in operating theatres. Early development of these SFOV cameras was focussed on a single modality—gamma ray imaging. Recently, a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5375840/ https://www.ncbi.nlm.nih.gov/pubmed/28282957 http://dx.doi.org/10.3390/s17030554 |
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author | Lees, John E. Bugby, Sarah L. Alqahtani, Mohammed S. Jambi, Layal K. Dawood, Numan S. McKnight, William R. Ng, Aik H. Perkins, Alan C. |
author_facet | Lees, John E. Bugby, Sarah L. Alqahtani, Mohammed S. Jambi, Layal K. Dawood, Numan S. McKnight, William R. Ng, Aik H. Perkins, Alan C. |
author_sort | Lees, John E. |
collection | PubMed |
description | The development of low profile gamma-ray detectors has encouraged the production of small field of view (SFOV) hand-held imaging devices for use at the patient bedside and in operating theatres. Early development of these SFOV cameras was focussed on a single modality—gamma ray imaging. Recently, a hybrid system—gamma plus optical imaging—has been developed. This combination of optical and gamma cameras enables high spatial resolution multi-modal imaging, giving a superimposed scintigraphic and optical image. Hybrid imaging offers new possibilities for assisting clinicians and surgeons in localising the site of uptake in procedures such as sentinel node detection. The hybrid camera concept can be extended to a multimodal detector design which can offer stereoscopic images, depth estimation of gamma-emitting sources, and simultaneous gamma and fluorescence imaging. Recent improvements to the hybrid camera have been used to produce dual-modality images in both laboratory simulations and in the clinic. Hybrid imaging of a patient who underwent thyroid scintigraphy is reported. In addition, we present data which shows that the hybrid camera concept can be extended to estimate the position and depth of radionuclide distribution within an object and also report the first combined gamma and Near-Infrared (NIR) fluorescence images. |
format | Online Article Text |
id | pubmed-5375840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53758402017-04-10 A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging Lees, John E. Bugby, Sarah L. Alqahtani, Mohammed S. Jambi, Layal K. Dawood, Numan S. McKnight, William R. Ng, Aik H. Perkins, Alan C. Sensors (Basel) Article The development of low profile gamma-ray detectors has encouraged the production of small field of view (SFOV) hand-held imaging devices for use at the patient bedside and in operating theatres. Early development of these SFOV cameras was focussed on a single modality—gamma ray imaging. Recently, a hybrid system—gamma plus optical imaging—has been developed. This combination of optical and gamma cameras enables high spatial resolution multi-modal imaging, giving a superimposed scintigraphic and optical image. Hybrid imaging offers new possibilities for assisting clinicians and surgeons in localising the site of uptake in procedures such as sentinel node detection. The hybrid camera concept can be extended to a multimodal detector design which can offer stereoscopic images, depth estimation of gamma-emitting sources, and simultaneous gamma and fluorescence imaging. Recent improvements to the hybrid camera have been used to produce dual-modality images in both laboratory simulations and in the clinic. Hybrid imaging of a patient who underwent thyroid scintigraphy is reported. In addition, we present data which shows that the hybrid camera concept can be extended to estimate the position and depth of radionuclide distribution within an object and also report the first combined gamma and Near-Infrared (NIR) fluorescence images. MDPI 2017-03-09 /pmc/articles/PMC5375840/ /pubmed/28282957 http://dx.doi.org/10.3390/s17030554 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lees, John E. Bugby, Sarah L. Alqahtani, Mohammed S. Jambi, Layal K. Dawood, Numan S. McKnight, William R. Ng, Aik H. Perkins, Alan C. A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging |
title | A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging |
title_full | A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging |
title_fullStr | A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging |
title_full_unstemmed | A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging |
title_short | A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging |
title_sort | multimodality hybrid gamma-optical camera for intraoperative imaging |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5375840/ https://www.ncbi.nlm.nih.gov/pubmed/28282957 http://dx.doi.org/10.3390/s17030554 |
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