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Conversion coefficients for determination of dispersed photon dose during radiotherapy: NRUrad input code for MCNP

Radiotherapy is a common cancer treatment module, where a certain amount of dose will be delivered to the targeted organ. This is achieved usually by photons generated by linear accelerator units. However, radiation scattering within the patient’s body and the surrounding environment will lead to do...

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Autores principales: Shahmohammadi Beni, Mehrdad, Ng, C. Y. P., Krstic, D., Nikezic, D., Yu, K. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376080/
https://www.ncbi.nlm.nih.gov/pubmed/28362837
http://dx.doi.org/10.1371/journal.pone.0174836
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author Shahmohammadi Beni, Mehrdad
Ng, C. Y. P.
Krstic, D.
Nikezic, D.
Yu, K. N.
author_facet Shahmohammadi Beni, Mehrdad
Ng, C. Y. P.
Krstic, D.
Nikezic, D.
Yu, K. N.
author_sort Shahmohammadi Beni, Mehrdad
collection PubMed
description Radiotherapy is a common cancer treatment module, where a certain amount of dose will be delivered to the targeted organ. This is achieved usually by photons generated by linear accelerator units. However, radiation scattering within the patient’s body and the surrounding environment will lead to dose dispersion to healthy tissues which are not targets of the primary radiation. Determination of the dispersed dose would be important for assessing the risk and biological consequences in different organs or tissues. In the present work, the concept of conversion coefficient (F) of the dispersed dose was developed, in which F = (D(d)/D(t)), where D(d) was the dispersed dose in a non-targeted tissue and D(t) is the absorbed dose in the targeted tissue. To quantify D(d) and D(t), a comprehensive model was developed using the Monte Carlo N-Particle (MCNP) package to simulate the linear accelerator head, the human phantom, the treatment couch and the radiotherapy treatment room. The present work also demonstrated the feasibility and power of parallel computing through the use of the Message Passing Interface (MPI) version of MCNP5.
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spelling pubmed-53760802017-04-07 Conversion coefficients for determination of dispersed photon dose during radiotherapy: NRUrad input code for MCNP Shahmohammadi Beni, Mehrdad Ng, C. Y. P. Krstic, D. Nikezic, D. Yu, K. N. PLoS One Research Article Radiotherapy is a common cancer treatment module, where a certain amount of dose will be delivered to the targeted organ. This is achieved usually by photons generated by linear accelerator units. However, radiation scattering within the patient’s body and the surrounding environment will lead to dose dispersion to healthy tissues which are not targets of the primary radiation. Determination of the dispersed dose would be important for assessing the risk and biological consequences in different organs or tissues. In the present work, the concept of conversion coefficient (F) of the dispersed dose was developed, in which F = (D(d)/D(t)), where D(d) was the dispersed dose in a non-targeted tissue and D(t) is the absorbed dose in the targeted tissue. To quantify D(d) and D(t), a comprehensive model was developed using the Monte Carlo N-Particle (MCNP) package to simulate the linear accelerator head, the human phantom, the treatment couch and the radiotherapy treatment room. The present work also demonstrated the feasibility and power of parallel computing through the use of the Message Passing Interface (MPI) version of MCNP5. Public Library of Science 2017-03-31 /pmc/articles/PMC5376080/ /pubmed/28362837 http://dx.doi.org/10.1371/journal.pone.0174836 Text en © 2017 Shahmohammadi Beni et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Shahmohammadi Beni, Mehrdad
Ng, C. Y. P.
Krstic, D.
Nikezic, D.
Yu, K. N.
Conversion coefficients for determination of dispersed photon dose during radiotherapy: NRUrad input code for MCNP
title Conversion coefficients for determination of dispersed photon dose during radiotherapy: NRUrad input code for MCNP
title_full Conversion coefficients for determination of dispersed photon dose during radiotherapy: NRUrad input code for MCNP
title_fullStr Conversion coefficients for determination of dispersed photon dose during radiotherapy: NRUrad input code for MCNP
title_full_unstemmed Conversion coefficients for determination of dispersed photon dose during radiotherapy: NRUrad input code for MCNP
title_short Conversion coefficients for determination of dispersed photon dose during radiotherapy: NRUrad input code for MCNP
title_sort conversion coefficients for determination of dispersed photon dose during radiotherapy: nrurad input code for mcnp
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376080/
https://www.ncbi.nlm.nih.gov/pubmed/28362837
http://dx.doi.org/10.1371/journal.pone.0174836
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