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GABA(A) receptor-expressing neurons promote consumption in Drosophila melanogaster
Feeding decisions are highly plastic and bidirectionally regulated by neurons that either promote or inhibit feeding. In Drosophila melanogaster, recent studies have identified four GABAergic interneurons that act as critical brakes to prevent incessant feeding. These GABAergic neurons may inhibit t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376345/ https://www.ncbi.nlm.nih.gov/pubmed/28362856 http://dx.doi.org/10.1371/journal.pone.0175177 |
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author | Cheung, Samantha K. Scott, Kristin |
author_facet | Cheung, Samantha K. Scott, Kristin |
author_sort | Cheung, Samantha K. |
collection | PubMed |
description | Feeding decisions are highly plastic and bidirectionally regulated by neurons that either promote or inhibit feeding. In Drosophila melanogaster, recent studies have identified four GABAergic interneurons that act as critical brakes to prevent incessant feeding. These GABAergic neurons may inhibit target neurons that drive consumption. Here, we tested this hypothesis by examining GABA receptors and neurons that promote consumption. We find that Resistance to dieldrin (RDL), a GABA(A) type receptor, is required for proper control of ingestion. Knockdown of Rdl in a subset of neurons causes overconsumption of tastants. Acute activation of these neurons is sufficient to drive consumption of appetitive substances and non-appetitive substances and acute silencing of these neurons decreases consumption. Taken together, these studies identify GABA(A) receptor-expressing neurons that promote Drosophila ingestive behavior and provide insight into feeding regulation. |
format | Online Article Text |
id | pubmed-5376345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-53763452017-04-07 GABA(A) receptor-expressing neurons promote consumption in Drosophila melanogaster Cheung, Samantha K. Scott, Kristin PLoS One Research Article Feeding decisions are highly plastic and bidirectionally regulated by neurons that either promote or inhibit feeding. In Drosophila melanogaster, recent studies have identified four GABAergic interneurons that act as critical brakes to prevent incessant feeding. These GABAergic neurons may inhibit target neurons that drive consumption. Here, we tested this hypothesis by examining GABA receptors and neurons that promote consumption. We find that Resistance to dieldrin (RDL), a GABA(A) type receptor, is required for proper control of ingestion. Knockdown of Rdl in a subset of neurons causes overconsumption of tastants. Acute activation of these neurons is sufficient to drive consumption of appetitive substances and non-appetitive substances and acute silencing of these neurons decreases consumption. Taken together, these studies identify GABA(A) receptor-expressing neurons that promote Drosophila ingestive behavior and provide insight into feeding regulation. Public Library of Science 2017-03-31 /pmc/articles/PMC5376345/ /pubmed/28362856 http://dx.doi.org/10.1371/journal.pone.0175177 Text en © 2017 Cheung, Scott http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Cheung, Samantha K. Scott, Kristin GABA(A) receptor-expressing neurons promote consumption in Drosophila melanogaster |
title | GABA(A) receptor-expressing neurons promote consumption in Drosophila melanogaster |
title_full | GABA(A) receptor-expressing neurons promote consumption in Drosophila melanogaster |
title_fullStr | GABA(A) receptor-expressing neurons promote consumption in Drosophila melanogaster |
title_full_unstemmed | GABA(A) receptor-expressing neurons promote consumption in Drosophila melanogaster |
title_short | GABA(A) receptor-expressing neurons promote consumption in Drosophila melanogaster |
title_sort | gaba(a) receptor-expressing neurons promote consumption in drosophila melanogaster |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376345/ https://www.ncbi.nlm.nih.gov/pubmed/28362856 http://dx.doi.org/10.1371/journal.pone.0175177 |
work_keys_str_mv | AT cheungsamanthak gabaareceptorexpressingneuronspromoteconsumptionindrosophilamelanogaster AT scottkristin gabaareceptorexpressingneuronspromoteconsumptionindrosophilamelanogaster |