Cargando…
Can Mitochondria DNA Provide a Novel Biomarker for Evaluating the Risk and Prognosis of Colorectal Cancer?
Colorectal cancer (CRC) was one of the most frequent cancers worldwide. Accurate risk and prognosis evaluation could obtain better quality of life and longer survival time for the patients. Current research hotspot was focus on the gene biomarker to evaluate the risk and prognosis. Mitochondrion con...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376434/ https://www.ncbi.nlm.nih.gov/pubmed/28408773 http://dx.doi.org/10.1155/2017/5189803 |
_version_ | 1782519157192916992 |
---|---|
author | Shuwen, Han Xi, Yang Yuefen, Pan |
author_facet | Shuwen, Han Xi, Yang Yuefen, Pan |
author_sort | Shuwen, Han |
collection | PubMed |
description | Colorectal cancer (CRC) was one of the most frequent cancers worldwide. Accurate risk and prognosis evaluation could obtain better quality of life and longer survival time for the patients. Current research hotspot was focus on the gene biomarker to evaluate the risk and prognosis. Mitochondrion contains its own DNA and regulates self-replicating so that it can be as a candidate biomarker for evaluating the risk and prognosis of colorectal cancer. But there were already huge controversies on this issue. The review was to summarize current viewpoints of the controversial issues and described our understanding from the four aspects including mtDNA copy number, mitochondrial displacement loop, mtDNA variation, and mtDNA microsatellite instability, wishing the summary of the mtDNA in colorectal cancer could provide a meaningful reference or a valuable direction in the future studies. |
format | Online Article Text |
id | pubmed-5376434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-53764342017-04-13 Can Mitochondria DNA Provide a Novel Biomarker for Evaluating the Risk and Prognosis of Colorectal Cancer? Shuwen, Han Xi, Yang Yuefen, Pan Dis Markers Review Article Colorectal cancer (CRC) was one of the most frequent cancers worldwide. Accurate risk and prognosis evaluation could obtain better quality of life and longer survival time for the patients. Current research hotspot was focus on the gene biomarker to evaluate the risk and prognosis. Mitochondrion contains its own DNA and regulates self-replicating so that it can be as a candidate biomarker for evaluating the risk and prognosis of colorectal cancer. But there were already huge controversies on this issue. The review was to summarize current viewpoints of the controversial issues and described our understanding from the four aspects including mtDNA copy number, mitochondrial displacement loop, mtDNA variation, and mtDNA microsatellite instability, wishing the summary of the mtDNA in colorectal cancer could provide a meaningful reference or a valuable direction in the future studies. Hindawi 2017 2017-03-16 /pmc/articles/PMC5376434/ /pubmed/28408773 http://dx.doi.org/10.1155/2017/5189803 Text en Copyright © 2017 Han Shuwen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Shuwen, Han Xi, Yang Yuefen, Pan Can Mitochondria DNA Provide a Novel Biomarker for Evaluating the Risk and Prognosis of Colorectal Cancer? |
title | Can Mitochondria DNA Provide a Novel Biomarker for Evaluating the Risk and Prognosis of Colorectal Cancer? |
title_full | Can Mitochondria DNA Provide a Novel Biomarker for Evaluating the Risk and Prognosis of Colorectal Cancer? |
title_fullStr | Can Mitochondria DNA Provide a Novel Biomarker for Evaluating the Risk and Prognosis of Colorectal Cancer? |
title_full_unstemmed | Can Mitochondria DNA Provide a Novel Biomarker for Evaluating the Risk and Prognosis of Colorectal Cancer? |
title_short | Can Mitochondria DNA Provide a Novel Biomarker for Evaluating the Risk and Prognosis of Colorectal Cancer? |
title_sort | can mitochondria dna provide a novel biomarker for evaluating the risk and prognosis of colorectal cancer? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376434/ https://www.ncbi.nlm.nih.gov/pubmed/28408773 http://dx.doi.org/10.1155/2017/5189803 |
work_keys_str_mv | AT shuwenhan canmitochondriadnaprovideanovelbiomarkerforevaluatingtheriskandprognosisofcolorectalcancer AT xiyang canmitochondriadnaprovideanovelbiomarkerforevaluatingtheriskandprognosisofcolorectalcancer AT yuefenpan canmitochondriadnaprovideanovelbiomarkerforevaluatingtheriskandprognosisofcolorectalcancer |