Increased Oxidative Stress Markers in Cerebrospinal Fluid from Healthy Subjects with Parkinson’s Disease-Associated LRRK2 Gene Mutations

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most frequent cause of inherited Parkinson’s disease (PD). The most common PD-associated LRRK2 mutation, G2019S, induces increased production of reactive oxygen species in vitro. We therefore hypothesized that individuals with PD-ass...

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Detalles Bibliográficos
Autores principales: Loeffler, David A., Klaver, Andrea C., Coffey, Mary P., Aasly, Jan O., LeWitt, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376564/
https://www.ncbi.nlm.nih.gov/pubmed/28420983
http://dx.doi.org/10.3389/fnagi.2017.00089

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