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Organ-to-Organ Communication: A Drosophila Gastrointestinal Tract Perspective

The long-term maintenance of an organism's homeostasis and health relies on the accurate regulation of organ-organ communication. Recently, there has been growing interest in using the Drosophila gastrointestinal tract to elucidate the regulatory programs that underlie the complex interactions...

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Autores principales: Liu, Qiang, Jin, Li Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376570/
https://www.ncbi.nlm.nih.gov/pubmed/28421183
http://dx.doi.org/10.3389/fcell.2017.00029
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author Liu, Qiang
Jin, Li Hua
author_facet Liu, Qiang
Jin, Li Hua
author_sort Liu, Qiang
collection PubMed
description The long-term maintenance of an organism's homeostasis and health relies on the accurate regulation of organ-organ communication. Recently, there has been growing interest in using the Drosophila gastrointestinal tract to elucidate the regulatory programs that underlie the complex interactions between organs. Data obtained in this field have dramatically improved our understanding of how organ-organ communication contributes to the regulation of various aspects of the intestine, including its metabolic and physiological status. However, although research uncovering regulatory programs associated with interorgan communication has provided key insights, the underlying mechanisms have not been extensively explored. In this review, we highlight recent findings describing gut-neighbor and neighbor-neighbor communication models in adults and larvae, respectively, with a special focus on how a range of critical strategies concerning continuous interorgan communication and adjustment can be used to manipulate different aspects of biological processes. Given the high degree of similarity between the Drosophila and mammalian intestinal epithelia, it can be anticipated that further analyses of the Drosophila gastrointestinal tract will facilitate the discovery of similar mechanisms underlying organ-organ communication in other mammalian organs, such as the human intestine.
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spelling pubmed-53765702017-04-18 Organ-to-Organ Communication: A Drosophila Gastrointestinal Tract Perspective Liu, Qiang Jin, Li Hua Front Cell Dev Biol Cell and Developmental Biology The long-term maintenance of an organism's homeostasis and health relies on the accurate regulation of organ-organ communication. Recently, there has been growing interest in using the Drosophila gastrointestinal tract to elucidate the regulatory programs that underlie the complex interactions between organs. Data obtained in this field have dramatically improved our understanding of how organ-organ communication contributes to the regulation of various aspects of the intestine, including its metabolic and physiological status. However, although research uncovering regulatory programs associated with interorgan communication has provided key insights, the underlying mechanisms have not been extensively explored. In this review, we highlight recent findings describing gut-neighbor and neighbor-neighbor communication models in adults and larvae, respectively, with a special focus on how a range of critical strategies concerning continuous interorgan communication and adjustment can be used to manipulate different aspects of biological processes. Given the high degree of similarity between the Drosophila and mammalian intestinal epithelia, it can be anticipated that further analyses of the Drosophila gastrointestinal tract will facilitate the discovery of similar mechanisms underlying organ-organ communication in other mammalian organs, such as the human intestine. Frontiers Media S.A. 2017-04-03 /pmc/articles/PMC5376570/ /pubmed/28421183 http://dx.doi.org/10.3389/fcell.2017.00029 Text en Copyright © 2017 Liu and Jin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Liu, Qiang
Jin, Li Hua
Organ-to-Organ Communication: A Drosophila Gastrointestinal Tract Perspective
title Organ-to-Organ Communication: A Drosophila Gastrointestinal Tract Perspective
title_full Organ-to-Organ Communication: A Drosophila Gastrointestinal Tract Perspective
title_fullStr Organ-to-Organ Communication: A Drosophila Gastrointestinal Tract Perspective
title_full_unstemmed Organ-to-Organ Communication: A Drosophila Gastrointestinal Tract Perspective
title_short Organ-to-Organ Communication: A Drosophila Gastrointestinal Tract Perspective
title_sort organ-to-organ communication: a drosophila gastrointestinal tract perspective
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376570/
https://www.ncbi.nlm.nih.gov/pubmed/28421183
http://dx.doi.org/10.3389/fcell.2017.00029
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