Identification of Rare PB2-D701N Mutation from a Patient with Severe Influenza: Contribution of the PB2-D701N Mutation to the Pathogenicity of Human Influenza

Several amino acid changes have been previously implicated in adaptation of avian influenza viruses to human hosts, among them the D701N change in the PB2 polymerase subunit that also is the main determinant of avian virus pathogenesis in animal models. However, previous studies using recombinant vi...

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Detalles Bibliográficos
Autores principales: Nieto, Amelia, Pozo, Francisco, Vidal-García, Matxalen, Omeñaca, Manuel, Casas, Inmaculada, Falcón, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376584/
https://www.ncbi.nlm.nih.gov/pubmed/28421062
http://dx.doi.org/10.3389/fmicb.2017.00575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376584/
https://www.ncbi.nlm.nih.gov/pubmed/28421062
http://dx.doi.org/10.3389/fmicb.2017.00575

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