NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization

Antigen-specific adhesion between T cells and antigen-presenting cells (APC) during the formation of the immunological synapse (IS) is mediated by LFA-1 and ICAM-1. Here, LFA-1–ICAM-1 interactions were measured at the single-molecule level on supported lipid bilayers. High-affinity binding was detec...

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Detalles Bibliográficos
Autores principales: Kondo, Naoyuki, Ueda, Yoshihiro, Kita, Toshiyuki, Ozawa, Madoka, Tomiyama, Takashi, Yasuda, Kaneki, Lim, Dae-Sik, Kinashi, Tatsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376635/
https://www.ncbi.nlm.nih.gov/pubmed/28137909
http://dx.doi.org/10.1128/MCB.00424-16

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