Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

A number of human diseases, such as arthritis and atherosclerosis, include characteristic pathology in specific anatomical locations. Here we show transcriptomic differences in synovial fibroblasts from different joint locations and that HOX gene signatures reflect the joint-specific origins of mous...

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Detalles Bibliográficos
Autores principales: Frank-Bertoncelj, Mojca, Trenkmann, Michelle, Klein, Kerstin, Karouzakis, Emmanuel, Rehrauer, Hubert, Bratus, Anna, Kolling, Christoph, Armaka, Maria, Filer, Andrew, Michel, Beat A., Gay, Renate E., Buckley, Christopher D., Kollias, George, Gay, Steffen, Ospelt, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376654/
https://www.ncbi.nlm.nih.gov/pubmed/28332497
http://dx.doi.org/10.1038/ncomms14852

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