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Ubiquitin E3 ligase Itch negatively regulates osteoblast function by promoting proteasome degradation of osteogenic proteins

OBJECTIVES: Ubiquitin E3 ligase-mediated protein degradation regulates osteoblast function. Itch, an E3 ligase, affects numerous cell functions by regulating ubiquitination and proteasomal degradation of related proteins. However, the Itch-related cellular and molecular mechanisms by which osteoblas...

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Detalles Bibliográficos
Autores principales:	Liu, J., Li, X., Zhang, H., Gu, R., Wang, Z., Gao, Z., Xing, L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376659/ https://www.ncbi.nlm.nih.gov/pubmed/28298321 http://dx.doi.org/10.1302/2046-3758.63.BJR-2016-0237.R1

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