Cargando…

Ubiquitin E3 ligase Itch negatively regulates osteoblast function by promoting proteasome degradation of osteogenic proteins

OBJECTIVES: Ubiquitin E3 ligase-mediated protein degradation regulates osteoblast function. Itch, an E3 ligase, affects numerous cell functions by regulating ubiquitination and proteasomal degradation of related proteins. However, the Itch-related cellular and molecular mechanisms by which osteoblas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, J., Li, X., Zhang, H., Gu, R., Wang, Z., Gao, Z., Xing, L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376659/ https://www.ncbi.nlm.nih.gov/pubmed/28298321 http://dx.doi.org/10.1302/2046-3758.63.BJR-2016-0237.R1

Ejemplares similares

ITCH E3 ubiquitin ligase downregulation compromises hepatic degradation of branched-chain amino acids
por: Menghini, Rossella, et al.
Publicado: (2022)

The E3 ubiquitin ligase Itch is required for B-cell development
por: Liu, Xiaoling, et al.
Publicado: (2019)

ZSCAN4 is negatively regulated by the ubiquitin-proteasome system and the E3 ubiquitin ligase RNF20
por: Portney, Benjamin A., et al.
Publicado: (2018)

ATM kinase activity modulates ITCH E3-ubiquitin ligase activity
por: Santini, Simonetta, et al.
Publicado: (2013)

Immune regulation by protein ubiquitination: roles of the E3 ligases VHL and Itch
por: Aki, Daisuke, et al.
Publicado: (2018)

E6AP, an E3 ubiquitin ligase negatively regulates granulopoiesis by targeting transcription factor C/EBPα for ubiquitin-mediated proteasome degradation
por: Pal, P, et al.
Publicado: (2013)

The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3
por: Song, Hui, et al.
Publicado: (2016)

The E3 ubiquitin ligase Itch restricts antigen-driven B cell responses
por: Moser, Emily K., et al.
Publicado: (2019)

E3-ligase knock down revealed differential titin degradation by autophagy and the ubiquitin proteasome system
por: Müller, Erik, et al.
Publicado: (2021)

The Homeodomain Transcription Factor Hoxa2 Interacts with and Promotes the Proteasomal Degradation of the E3 Ubiquitin Protein Ligase RCHY1
por: Bergiers, Isabelle, et al.
Publicado: (2013)

Negative correlation of ITCH E3 ubiquitin ligase and miRNA-106b dictates metastatic progression in pancreatic cancer
por: Luo, Zhu-lin, et al.
Publicado: (2015)

Itch E3 Ubiquitin Ligase Positively Regulates TGF-β Signaling to EMT via Smad7 Ubiquitination
por: Park, Su-hyun, et al.
Publicado: (2015)

ITCH E3 ligase in ATM network
por: Stagni, Venturina, et al.
Publicado: (2014)

The E3 protein ubiquitin ligase Itch is a potential target in myeloid malignancies with marrow fibrosis
por: Han, Shuang, et al.
Publicado: (2021)

HIV-1 Tat Recruits HDM2 E3 Ligase To Target IRF-1 for Ubiquitination and Proteasomal Degradation
por: Remoli, Anna Lisa, et al.
Publicado: (2016)

The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasome-mediated degradation of PPARγ
por: Lee, Jae Min, et al.
Publicado: (2018)

E3 ligase adaptor FBXO7 contributes to ubiquitination and proteasomal degradation of SIRT7 and promotes cell death in response to hydrogen peroxide
por: Lee, Su Hyoun, et al.
Publicado: (2023)

E3 Ubiquitin Ligase-Mediated Regulation of Osteoblast Differentiation and Bone Formation
por: Shen, Jianlin, et al.
Publicado: (2021)

E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation
por: Liu, Liu, et al.
Publicado: (2020)

HECT ubiquitin ligases as accessory proteins of the plant proteasome
por: Wang, Zhishuo, et al.
Publicado: (2022)

FBXW7 E3 ubiquitin ligase: degrading, not degrading, or being degraded
por: Lan, Huiyin, et al.
Publicado: (2019)

Cullin 3(SPOP) ubiquitin E3 ligase promotes the poly-ubiquitination and degradation of HDAC6
por: Tan, Yuyong, et al.
Publicado: (2017)

Antibody targeting of E3 ubiquitin ligases for receptor degradation
por: Marei, Hadir, et al.
Publicado: (2022)

HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity
por: ZeRuth, Gary T., et al.
Publicado: (2015)

The E3 Ubiquitin Ligase SIAH1 Targets MyD88 for Proteasomal Degradation During Dengue Virus Infection
por: Murphy Schafer, Ashleigh R., et al.
Publicado: (2020)

The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway
por: Salah, Zaidoun, et al.
Publicado: (2014)

MYPT1 Down-regulation by Lipopolysaccharide-SIAH1/2 E3 Ligase-Ubiquitin-Proteasomal Degradation Contributes to Colonic Obstruction of Hirschsprung Disease
por: Zhao, W., et al.
Publicado: (2019)

Necdin Promotes Ubiquitin-Dependent Degradation of PIAS1 SUMO E3 Ligase
por: Gur, Ibrahim, et al.
Publicado: (2014)

The E3 Ubiquitin Ligase TRIM21 Promotes HBV DNA Polymerase Degradation
por: Mu, Ting, et al.
Publicado: (2020)

The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein
por: Kwon, Deborah Y., et al.
Publicado: (2013)

SIMPLE/LITAF Expression Induces the Translocation of the Ubiquitin Ligase Itch towards the Lysosomal Compartments
por: Eaton, Heather E., et al.
Publicado: (2011)

Ubiquitin ligase ITCH recruitment suppresses the aggregation and cellular toxicity of cytoplasmic misfolded proteins
por: Chhangani, Deepak, et al.
Publicado: (2014)

TRIM27 Negatively Regulates NOD2 by Ubiquitination and Proteasomal Degradation
por: Zurek, Birte, et al.
Publicado: (2012)

The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a
por: Sparks, A, et al.
Publicado: (2014)

Extracellular LDLR repeats modulate Wnt signaling activity by promoting LRP6 receptor endocytosis mediated by the Itch E3 ubiquitin ligase
por: Vijayakumar, Sapna, et al.
Publicado: (2017)

TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2
por: Li, Jinteng, et al.
Publicado: (2019)

High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy
por: Rossi, M, et al.
Publicado: (2014)

PRMT5 epigenetically regulates the E3 ubiquitin ligase ITCH to influence lipid accumulation during mycobacterial infection
por: Borbora, Salik Miskat, et al.
Publicado: (2022)

The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR
por: Zeng, Shenglan, et al.
Publicado: (2021)

SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage
por: Hong, Xuehui, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_6tvulnsdr8kr3k9atokfdo9voe