A Case of Blastic Plasmacytoid Dendritic Cell Neoplasm Extensively Studied by Flow Cytometry and Immunohistochemistry

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with aggressive clinical course and poor prognosis. Diagnosis is based on detection of CD4(+) CD56(+), CD123(high), TCL-1(+), and blood dendritic cell antigen-2/CD303(+) blasts, together with the absence of lineage...

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Autores principales: Pennisi, Martina, Cesana, Clara, Cittone, Micol Giulia, Bandiera, Laura, Scarpati, Barbara, Mancini, Valentina, Soriani, Silvia, Veronese, Silvio, Truini, Mauro, Rossini, Silvano, Cairoli, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376917/
https://www.ncbi.nlm.nih.gov/pubmed/28409040
http://dx.doi.org/10.1155/2017/4984951
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author Pennisi, Martina
Cesana, Clara
Cittone, Micol Giulia
Bandiera, Laura
Scarpati, Barbara
Mancini, Valentina
Soriani, Silvia
Veronese, Silvio
Truini, Mauro
Rossini, Silvano
Cairoli, Roberto
author_facet Pennisi, Martina
Cesana, Clara
Cittone, Micol Giulia
Bandiera, Laura
Scarpati, Barbara
Mancini, Valentina
Soriani, Silvia
Veronese, Silvio
Truini, Mauro
Rossini, Silvano
Cairoli, Roberto
author_sort Pennisi, Martina
collection PubMed
description Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with aggressive clinical course and poor prognosis. Diagnosis is based on detection of CD4(+) CD56(+), CD123(high), TCL-1(+), and blood dendritic cell antigen-2/CD303(+) blasts, together with the absence of lineage specific antigens on tumour cells. In this report we present a case of BPDCN presenting with extramedullary and bone marrow involvement, extensively studied by flow cytometry and immunohistochemistry, who achieved complete remission after acute lymphoblastic leukemia like chemotherapy and allogeneic hematopoietic stem cell transplantation.
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spelling pubmed-53769172017-04-13 A Case of Blastic Plasmacytoid Dendritic Cell Neoplasm Extensively Studied by Flow Cytometry and Immunohistochemistry Pennisi, Martina Cesana, Clara Cittone, Micol Giulia Bandiera, Laura Scarpati, Barbara Mancini, Valentina Soriani, Silvia Veronese, Silvio Truini, Mauro Rossini, Silvano Cairoli, Roberto Case Rep Hematol Case Report Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with aggressive clinical course and poor prognosis. Diagnosis is based on detection of CD4(+) CD56(+), CD123(high), TCL-1(+), and blood dendritic cell antigen-2/CD303(+) blasts, together with the absence of lineage specific antigens on tumour cells. In this report we present a case of BPDCN presenting with extramedullary and bone marrow involvement, extensively studied by flow cytometry and immunohistochemistry, who achieved complete remission after acute lymphoblastic leukemia like chemotherapy and allogeneic hematopoietic stem cell transplantation. Hindawi 2017 2017-03-20 /pmc/articles/PMC5376917/ /pubmed/28409040 http://dx.doi.org/10.1155/2017/4984951 Text en Copyright © 2017 Martina Pennisi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Pennisi, Martina
Cesana, Clara
Cittone, Micol Giulia
Bandiera, Laura
Scarpati, Barbara
Mancini, Valentina
Soriani, Silvia
Veronese, Silvio
Truini, Mauro
Rossini, Silvano
Cairoli, Roberto
A Case of Blastic Plasmacytoid Dendritic Cell Neoplasm Extensively Studied by Flow Cytometry and Immunohistochemistry
title A Case of Blastic Plasmacytoid Dendritic Cell Neoplasm Extensively Studied by Flow Cytometry and Immunohistochemistry
title_full A Case of Blastic Plasmacytoid Dendritic Cell Neoplasm Extensively Studied by Flow Cytometry and Immunohistochemistry
title_fullStr A Case of Blastic Plasmacytoid Dendritic Cell Neoplasm Extensively Studied by Flow Cytometry and Immunohistochemistry
title_full_unstemmed A Case of Blastic Plasmacytoid Dendritic Cell Neoplasm Extensively Studied by Flow Cytometry and Immunohistochemistry
title_short A Case of Blastic Plasmacytoid Dendritic Cell Neoplasm Extensively Studied by Flow Cytometry and Immunohistochemistry
title_sort case of blastic plasmacytoid dendritic cell neoplasm extensively studied by flow cytometry and immunohistochemistry
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376917/
https://www.ncbi.nlm.nih.gov/pubmed/28409040
http://dx.doi.org/10.1155/2017/4984951
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