Fatal Outcome of European Tick-borne Encephalitis after Vaccine Failure

Tick-borne encephalitis is a viral disease affecting the central nervous system. It is endemic in Switzerland with 200–250 notified cases annually. Active immunization is effective for persons in all age groups. Vaccine failure is rare, in particular after a completed vaccination course. Here, we de...

Descripción completa

Detalles Bibliográficos
Autores principales: Sendi, Parham, Hirzel, Cédric, Pfister, Stefan, Ackermann-Gäumann, Rahel, Grandgirard, Denis, Hewer, Ekkehard, Nirkko, Arto C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377060/
https://www.ncbi.nlm.nih.gov/pubmed/28421031
http://dx.doi.org/10.3389/fneur.2017.00119
_version_ 1782519238918930432
author Sendi, Parham
Hirzel, Cédric
Pfister, Stefan
Ackermann-Gäumann, Rahel
Grandgirard, Denis
Hewer, Ekkehard
Nirkko, Arto C.
author_facet Sendi, Parham
Hirzel, Cédric
Pfister, Stefan
Ackermann-Gäumann, Rahel
Grandgirard, Denis
Hewer, Ekkehard
Nirkko, Arto C.
author_sort Sendi, Parham
collection PubMed
description Tick-borne encephalitis is a viral disease affecting the central nervous system. It is endemic in Switzerland with 200–250 notified cases annually. Active immunization is effective for persons in all age groups. Vaccine failure is rare, in particular after a completed vaccination course. Here, we describe the case of 67-year-old man with a fatal outcome despite vaccination. The diagnosis was confirmed by extensive postmortem analyses. The diagnostic challenges of vaccine failure in tick-borne encephalitis and the dynamics of the immune response in vaccination breakthrough are discussed.
format Online
Article
Text
id pubmed-5377060
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-53770602017-04-18 Fatal Outcome of European Tick-borne Encephalitis after Vaccine Failure Sendi, Parham Hirzel, Cédric Pfister, Stefan Ackermann-Gäumann, Rahel Grandgirard, Denis Hewer, Ekkehard Nirkko, Arto C. Front Neurol Neuroscience Tick-borne encephalitis is a viral disease affecting the central nervous system. It is endemic in Switzerland with 200–250 notified cases annually. Active immunization is effective for persons in all age groups. Vaccine failure is rare, in particular after a completed vaccination course. Here, we describe the case of 67-year-old man with a fatal outcome despite vaccination. The diagnosis was confirmed by extensive postmortem analyses. The diagnostic challenges of vaccine failure in tick-borne encephalitis and the dynamics of the immune response in vaccination breakthrough are discussed. Frontiers Media S.A. 2017-04-03 /pmc/articles/PMC5377060/ /pubmed/28421031 http://dx.doi.org/10.3389/fneur.2017.00119 Text en Copyright © 2017 Sendi, Hirzel, Pfister, Ackermann-Gäumann, Grandgirard, Hewer and Nirkko. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Sendi, Parham
Hirzel, Cédric
Pfister, Stefan
Ackermann-Gäumann, Rahel
Grandgirard, Denis
Hewer, Ekkehard
Nirkko, Arto C.
Fatal Outcome of European Tick-borne Encephalitis after Vaccine Failure
title Fatal Outcome of European Tick-borne Encephalitis after Vaccine Failure
title_full Fatal Outcome of European Tick-borne Encephalitis after Vaccine Failure
title_fullStr Fatal Outcome of European Tick-borne Encephalitis after Vaccine Failure
title_full_unstemmed Fatal Outcome of European Tick-borne Encephalitis after Vaccine Failure
title_short Fatal Outcome of European Tick-borne Encephalitis after Vaccine Failure
title_sort fatal outcome of european tick-borne encephalitis after vaccine failure
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377060/
https://www.ncbi.nlm.nih.gov/pubmed/28421031
http://dx.doi.org/10.3389/fneur.2017.00119
work_keys_str_mv AT sendiparham fataloutcomeofeuropeantickborneencephalitisaftervaccinefailure
AT hirzelcedric fataloutcomeofeuropeantickborneencephalitisaftervaccinefailure
AT pfisterstefan fataloutcomeofeuropeantickborneencephalitisaftervaccinefailure
AT ackermanngaumannrahel fataloutcomeofeuropeantickborneencephalitisaftervaccinefailure
AT grandgirarddenis fataloutcomeofeuropeantickborneencephalitisaftervaccinefailure
AT hewerekkehard fataloutcomeofeuropeantickborneencephalitisaftervaccinefailure
AT nirkkoartoc fataloutcomeofeuropeantickborneencephalitisaftervaccinefailure

Ejemplares similares