Human Diseases Associated with Defective DNA Excision Repair

DNA excision repair is the process used by cells to remove damage from DNA such as that caused by ultraviolet light and many chemicals. Dysfunction of excision repair in humans can lead to heritable diseases in which individuals are sensitive to mutagens, and have an increased risk of skin cancer. T...

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Detalles Bibliográficos
Autor principal: Wood, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal College of Physicians of London 1991
Materias:
Overview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377154/
https://www.ncbi.nlm.nih.gov/pubmed/1960684
Descripción
Sumario:DNA excision repair is the process used by cells to remove damage from DNA such as that caused by ultraviolet light and many chemicals. Dysfunction of excision repair in humans can lead to heritable diseases in which individuals are sensitive to mutagens, and have an increased risk of skin cancer. The best studied syndrome of this type is xeroderma pigmentosum. Recent research has revealed the genes which encode several different components of DNA excision repair. Work has begun on the protein products encoded by these genes, with the aim of elucidating the detailed biochemical mechanism of the DNA excision repair pathway.

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