Human Diseases Associated with Defective DNA Excision Repair

DNA excision repair is the process used by cells to remove damage from DNA such as that caused by ultraviolet light and many chemicals. Dysfunction of excision repair in humans can lead to heritable diseases in which individuals are sensitive to mutagens, and have an increased risk of skin cancer. T...

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Detalles Bibliográficos
Autor principal: Wood, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal College of Physicians of London 1991
Materias:
Overview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377154/
https://www.ncbi.nlm.nih.gov/pubmed/1960684
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author Wood, Richard D.
author_facet Wood, Richard D.
author_sort Wood, Richard D.
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description DNA excision repair is the process used by cells to remove damage from DNA such as that caused by ultraviolet light and many chemicals. Dysfunction of excision repair in humans can lead to heritable diseases in which individuals are sensitive to mutagens, and have an increased risk of skin cancer. The best studied syndrome of this type is xeroderma pigmentosum. Recent research has revealed the genes which encode several different components of DNA excision repair. Work has begun on the protein products encoded by these genes, with the aim of elucidating the detailed biochemical mechanism of the DNA excision repair pathway.
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spelling pubmed-53771542019-01-22 Human Diseases Associated with Defective DNA Excision Repair Wood, Richard D. J R Coll Physicians Lond Overview DNA excision repair is the process used by cells to remove damage from DNA such as that caused by ultraviolet light and many chemicals. Dysfunction of excision repair in humans can lead to heritable diseases in which individuals are sensitive to mutagens, and have an increased risk of skin cancer. The best studied syndrome of this type is xeroderma pigmentosum. Recent research has revealed the genes which encode several different components of DNA excision repair. Work has begun on the protein products encoded by these genes, with the aim of elucidating the detailed biochemical mechanism of the DNA excision repair pathway. Royal College of Physicians of London 1991-10 /pmc/articles/PMC5377154/ /pubmed/1960684 Text en © Journal of the Royal College of Physicians of London 1991 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits non-commercial use and redistribution provided that the original author and source are credited.
spellingShingle Overview
Wood, Richard D.
Human Diseases Associated with Defective DNA Excision Repair
title Human Diseases Associated with Defective DNA Excision Repair
title_full Human Diseases Associated with Defective DNA Excision Repair
title_fullStr Human Diseases Associated with Defective DNA Excision Repair
title_full_unstemmed Human Diseases Associated with Defective DNA Excision Repair
title_short Human Diseases Associated with Defective DNA Excision Repair
title_sort human diseases associated with defective dna excision repair
topic Overview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377154/
https://www.ncbi.nlm.nih.gov/pubmed/1960684
work_keys_str_mv AT woodrichardd humandiseasesassociatedwithdefectivednaexcisionrepair

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