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A new target region for changing the substrate specificity of amine transaminases

(R)-stereospecific amine transaminases (R-ATAs) are important biocatalysts for the production of (R)-amine compounds in a strict stereospecific manner. An improved R-ATA, ATA-117-Rd11, was successfully engineered for the manufacture of sitagliptin, a widely used therapeutic agent for type-2 diabetes...

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Detalles Bibliográficos
Autores principales:	Guan, Li-Jun, Ohtsuka, Jun, Okai, Masahiko, Miyakawa, Takuya, Mase, Tomoko, Zhi, Yuehua, Hou, Feng, Ito, Noriyuki, Iwasaki, Akira, Yasohara, Yoshihiko, Tanokura, Masaru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377235/ https://www.ncbi.nlm.nih.gov/pubmed/26030619 http://dx.doi.org/10.1038/srep10753

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