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Diagnostic value of neutrophil gelatinase-associated lipocalin for renal injury in asphyxiated preterm infants
The aim of the present study was to analyze the diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) in renal injury in asphyxiated preterm infants. In total, 48 cases of asphyxiated preterm infants, 45 cases of premature infants and 45 cases of normal newborn infants were included...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377243/ https://www.ncbi.nlm.nih.gov/pubmed/28413463 http://dx.doi.org/10.3892/etm.2017.4107 |
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author | Song, Yu'E Sun, Shuzhen Yu, Yonghui Li, Gang Song, Jia Zhang, Hong Yan, Chunmei |
author_facet | Song, Yu'E Sun, Shuzhen Yu, Yonghui Li, Gang Song, Jia Zhang, Hong Yan, Chunmei |
author_sort | Song, Yu'E |
collection | PubMed |
description | The aim of the present study was to analyze the diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) in renal injury in asphyxiated preterm infants. In total, 48 cases of asphyxiated preterm infants, 45 cases of premature infants and 45 cases of normal newborn infants were included in the study. Using ELISA we evaluated the level of urine NGAL, kidney injury molecule-1 (KIM-1), cystatin C (Cys-C) and serum creatinine (Scr). We also calculated the estimated glomerular filtration rate (eGFR). Our results showed that NGAL, KIM-1 and Cys-C levels in the group of asphyxiant renal injury within 24 and 48 h were markedly higher than the other two groups (P<0.05), while changes in Scr and eGFR within 24 h were not significant (P>0.05). Scr level in renal injury group within 48 h was markedly elevated while the eGFR level was visibly reduced (P<0.05). According to analysis of receiver operating characteristic curve, area under curve for NGAL in the group of asphyxiant renal injury within 24 and 48 h was significantly higher than KIM-1 and Cys-C. Susceptibility and specificity were improved. In conclusion, diagnosis of renal injury in asphyxia neonates using NGAL was more efficient compared to other methods. |
format | Online Article Text |
id | pubmed-5377243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-53772432017-04-15 Diagnostic value of neutrophil gelatinase-associated lipocalin for renal injury in asphyxiated preterm infants Song, Yu'E Sun, Shuzhen Yu, Yonghui Li, Gang Song, Jia Zhang, Hong Yan, Chunmei Exp Ther Med Articles The aim of the present study was to analyze the diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) in renal injury in asphyxiated preterm infants. In total, 48 cases of asphyxiated preterm infants, 45 cases of premature infants and 45 cases of normal newborn infants were included in the study. Using ELISA we evaluated the level of urine NGAL, kidney injury molecule-1 (KIM-1), cystatin C (Cys-C) and serum creatinine (Scr). We also calculated the estimated glomerular filtration rate (eGFR). Our results showed that NGAL, KIM-1 and Cys-C levels in the group of asphyxiant renal injury within 24 and 48 h were markedly higher than the other two groups (P<0.05), while changes in Scr and eGFR within 24 h were not significant (P>0.05). Scr level in renal injury group within 48 h was markedly elevated while the eGFR level was visibly reduced (P<0.05). According to analysis of receiver operating characteristic curve, area under curve for NGAL in the group of asphyxiant renal injury within 24 and 48 h was significantly higher than KIM-1 and Cys-C. Susceptibility and specificity were improved. In conclusion, diagnosis of renal injury in asphyxia neonates using NGAL was more efficient compared to other methods. D.A. Spandidos 2017-04 2017-02-07 /pmc/articles/PMC5377243/ /pubmed/28413463 http://dx.doi.org/10.3892/etm.2017.4107 Text en Copyright: © Song et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Song, Yu'E Sun, Shuzhen Yu, Yonghui Li, Gang Song, Jia Zhang, Hong Yan, Chunmei Diagnostic value of neutrophil gelatinase-associated lipocalin for renal injury in asphyxiated preterm infants |
title | Diagnostic value of neutrophil gelatinase-associated lipocalin for renal injury in asphyxiated preterm infants |
title_full | Diagnostic value of neutrophil gelatinase-associated lipocalin for renal injury in asphyxiated preterm infants |
title_fullStr | Diagnostic value of neutrophil gelatinase-associated lipocalin for renal injury in asphyxiated preterm infants |
title_full_unstemmed | Diagnostic value of neutrophil gelatinase-associated lipocalin for renal injury in asphyxiated preterm infants |
title_short | Diagnostic value of neutrophil gelatinase-associated lipocalin for renal injury in asphyxiated preterm infants |
title_sort | diagnostic value of neutrophil gelatinase-associated lipocalin for renal injury in asphyxiated preterm infants |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377243/ https://www.ncbi.nlm.nih.gov/pubmed/28413463 http://dx.doi.org/10.3892/etm.2017.4107 |
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