Aggregation of polyglutamine-expanded ataxin-3 sequesters its specific interacting partners into inclusions: Implication in a loss-of-function pathology

Expansion of polyglutamine (polyQ) tract may cause protein misfolding and aggregation that lead to cytotoxicity and neurodegeneration, but the underlying mechanism remains to be elucidated. We applied ataxin-3 (Atx3), a polyQ tract-containing protein, as a model to study sequestration of normal cell...

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Detalles Bibliográficos
Autores principales: Yang, Hui, Li, Jing-Jing, Liu, Shuai, Zhao, Jian, Jiang, Ya-Jun, Song, Ai-Xin, Hu, Hong-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377324/
https://www.ncbi.nlm.nih.gov/pubmed/25231079
http://dx.doi.org/10.1038/srep06410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377324/
https://www.ncbi.nlm.nih.gov/pubmed/25231079
http://dx.doi.org/10.1038/srep06410

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