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A novel treatment for metastatic lymph nodes using lymphatic delivery and photothermal therapy
Systemic delivery of an anti-cancer agent often leads to only a small fraction of the administered dose accumulating in target sites. Delivering anti-cancer agents through the lymphatic network can achieve more efficient drug delivery for the treatment of lymph node metastasis. We show for the first...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377366/ https://www.ncbi.nlm.nih.gov/pubmed/28368042 http://dx.doi.org/10.1038/srep45459 |
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author | Oladipo, Adewale O. Oluwafemi, Oluwatobi S. Songca, Sandile P. Sukhbaatar, Ariunbuyan Mori, Shiro Okajima, Junnosuke Komiya, Atsuki Maruyama, Shigenao Kodama, Tetsuya |
author_facet | Oladipo, Adewale O. Oluwafemi, Oluwatobi S. Songca, Sandile P. Sukhbaatar, Ariunbuyan Mori, Shiro Okajima, Junnosuke Komiya, Atsuki Maruyama, Shigenao Kodama, Tetsuya |
author_sort | Oladipo, Adewale O. |
collection | PubMed |
description | Systemic delivery of an anti-cancer agent often leads to only a small fraction of the administered dose accumulating in target sites. Delivering anti-cancer agents through the lymphatic network can achieve more efficient drug delivery for the treatment of lymph node metastasis. We show for the first time that polymeric gold nanorods (PAuNRs) can be delivered efficiently from an accessory axillary lymph node to a tumor-containing proper axillary lymph node, enabling effective treatment of lymph node metastasis. In a mouse model of metastasis, lymphatic spread of tumor was inhibited by lymphatic-delivered PAuNRs and near-infrared laser irradiation, with the skin temperature controlled by cooling. Unlike intravenous injection, lymphatic injection delivered PAuNRs at a high concentration within a short period. The results show that lymphatic administration has the potential to deliver anti-cancer agents to metastatic lymph nodes for inhibition of tumor growth and could be developed into a new therapeutic method. |
format | Online Article Text |
id | pubmed-5377366 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-53773662017-04-10 A novel treatment for metastatic lymph nodes using lymphatic delivery and photothermal therapy Oladipo, Adewale O. Oluwafemi, Oluwatobi S. Songca, Sandile P. Sukhbaatar, Ariunbuyan Mori, Shiro Okajima, Junnosuke Komiya, Atsuki Maruyama, Shigenao Kodama, Tetsuya Sci Rep Article Systemic delivery of an anti-cancer agent often leads to only a small fraction of the administered dose accumulating in target sites. Delivering anti-cancer agents through the lymphatic network can achieve more efficient drug delivery for the treatment of lymph node metastasis. We show for the first time that polymeric gold nanorods (PAuNRs) can be delivered efficiently from an accessory axillary lymph node to a tumor-containing proper axillary lymph node, enabling effective treatment of lymph node metastasis. In a mouse model of metastasis, lymphatic spread of tumor was inhibited by lymphatic-delivered PAuNRs and near-infrared laser irradiation, with the skin temperature controlled by cooling. Unlike intravenous injection, lymphatic injection delivered PAuNRs at a high concentration within a short period. The results show that lymphatic administration has the potential to deliver anti-cancer agents to metastatic lymph nodes for inhibition of tumor growth and could be developed into a new therapeutic method. Nature Publishing Group 2017-04-03 /pmc/articles/PMC5377366/ /pubmed/28368042 http://dx.doi.org/10.1038/srep45459 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Oladipo, Adewale O. Oluwafemi, Oluwatobi S. Songca, Sandile P. Sukhbaatar, Ariunbuyan Mori, Shiro Okajima, Junnosuke Komiya, Atsuki Maruyama, Shigenao Kodama, Tetsuya A novel treatment for metastatic lymph nodes using lymphatic delivery and photothermal therapy |
title | A novel treatment for metastatic lymph nodes using lymphatic delivery and photothermal therapy |
title_full | A novel treatment for metastatic lymph nodes using lymphatic delivery and photothermal therapy |
title_fullStr | A novel treatment for metastatic lymph nodes using lymphatic delivery and photothermal therapy |
title_full_unstemmed | A novel treatment for metastatic lymph nodes using lymphatic delivery and photothermal therapy |
title_short | A novel treatment for metastatic lymph nodes using lymphatic delivery and photothermal therapy |
title_sort | novel treatment for metastatic lymph nodes using lymphatic delivery and photothermal therapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377366/ https://www.ncbi.nlm.nih.gov/pubmed/28368042 http://dx.doi.org/10.1038/srep45459 |
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