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Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways

The EtOAc extract of Coreopsis tinctoria Nutt. significantly inhibited LPS-induced nitric oxide (NO) production, as judged by the Griess reaction, and attenuated the LPS-induced elevation in iNOS, COX-2, IL-1β, IL-6 and TNF-α mRNA levels, as determined by quantitative real-time PCR, when incubated w...

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Detalles Bibliográficos
Autores principales:	Hou, Yue, Li, Guoxun, Wang, Jian, Pan, Yingni, Jiao, Kun, Du, Juan, Chen, Ru, Wang, Bing, Li, Ning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377376/ https://www.ncbi.nlm.nih.gov/pubmed/28367982 http://dx.doi.org/10.1038/srep45705

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